Abstract | BACKGROUND: CASE REPORTS: We report the cases of a 16-year-old girl and a 17-year-old boy who had Hodgkin's disease and developed painful and massive subcutaneous inflammatory edema after MINE chemotherapy. Morphine was unable to control pain leading to major functional disability of joint movement. One patient had an elevated creatine kinase level, hypoalbuminemia, hypodermic and muscular edema at magnetic resonance imaging and diffuse hemorrhagic hypodermic edema at skin biopsy. The other patient was found to have only hypoalbuminemia. The clinical course was favorable in both cases within a few weeks, but with recurrent episodes of pain and localized areas of fat necrosis five months later in one case. DISCUSSION:
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Authors | E Maubec, O Oberlin, K Belhadj, J C Roujeau |
Journal | Annales de dermatologie et de venereologie
(Ann Dermatol Venereol)
Vol. 128
Issue 4
Pg. 534-7
(Apr 2001)
ISSN: 0151-9638 [Print] France |
Vernacular Title | OEdème inflammatoire sous-cutané induit par une chimiothérapie de type MINE. |
PMID | 11395653
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Vinblastine
- Etoposide
- Creatine Kinase
- Mitoguazone
- Ifosfamide
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Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Biopsy
- Capillary Leak Syndrome
(chemically induced)
- Creatine Kinase
(blood)
- Edema
(chemically induced, complications, metabolism, pathology)
- Etoposide
(adverse effects)
- Fat Necrosis
(chemically induced)
- Female
- Hodgkin Disease
(drug therapy)
- Humans
- Ifosfamide
(adverse effects)
- Inflammation
- Magnetic Resonance Imaging
- Male
- Mitoguazone
(adverse effects)
- Pain
(chemically induced)
- Recurrence
- Vinblastine
(adverse effects, analogs & derivatives)
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