[Two cases of alpha-fetoprotein producing gastric cancer, showing marked response to continuous hepatic arterial infusion (HAI) chemotherapy with adriamycin].

Abstract

We report two cases of alpha-fetoprotein producing gastric cancer (AFPGC) with multiple liver metastases showing marked response to continuous HAI chemotherapy with adriamycin (ADM). In both cases, 5-FU 500 mg/body/day and Leucovorin (LV) 30 mg/body/day was infused continuously for 7 days and ADM 30 or 60 mg/body/day was infused continuously for 4 hours on day 7 as preoperative HAI chemotherapy. The primary gastric lesions were reduced and became resectable. After gastrectomy, they were treated with 4-hour continuous HAI of ADM 30 or 60 mg/body with or without 5-FU and LV once a week several times in our outpatient clinic. After these treatments, the multiple liver metastases were reduced remarkably, with a marked decrease of serum AFP levels. During these treatments, neither patient showed remarkable side effects, so they could work as before. This frequently low-dose ADM administration resulted in a high local response without severe side effects.

• Authors: K Shimazu, M Yasuno, K Takahashi, Y Iwasaki, K Arai, T Mori
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 28 Issue 5 Pg. 685-8 (May 2001) ISSN: 0385-0684 [Print] Japan
• PMID: 11383218 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• alpha-Fetoproteins
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Gastrectomy
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (secondary)
• Male
• Middle Aged
• Stomach Neoplasms (drug therapy, metabolism, pathology)
• alpha-Fetoproteins (biosynthesis)