Methyl Alcohol is an aliphatic alcohol with use in a few cosmetic formulations as a
solvent and denaturant. Concentrations up to 5% are typically used to denature
ethyl alcohol in cosmetic products.
Methyl Alcohol is readily absorbed through the skin and from the gastrointestinal and respiratory tracts, is distributed throughout all organs and tissues (in direct relation to the body's water distribution), and is eliminated primarily via the lungs. Undiluted
Methyl Alcohol is an ocular and skin
irritant. Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for teratogenic effects of 5,000 ppm. Overall,
Methyl Alcohol is not considered mutagenic. Carcinogenicity data were unavailable. The toxicity of
Methyl Alcohol in humans results from the metabolism of the alcohol to
formate and
formic acid through a
formaldehyde intermediate.
Formate accumulation causes
metabolic acidosis and inhibits cellular respiration.
Methyl Alcohol toxicity is time and concentration dependent, and its toxic effect is competitively inhibited with
ethyl alcohol. Because of the moderating effect of
ethyl alcohol, it was concluded that
Methyl Alcohol is safe as used to denature
ethyl alcohol used in cosmetic products. No conclusion was reached regarding any other use of
Methyl Alcohol.