Abstract | OBJECTIVE: METHODS: RESULTS: Median homocarnosine levels were normal for patients with JME and below normal for patients with CPS. Better seizure control was associated with higher homocarnosine levels for both groups. Median GABA was below normal for patients with JME, lower than for patients with CPS. Brain GABA was lowest in patients with JME even when seizure control was excellent. Pyrrolidinone levels were above normal in almost all patients with JME. CONCLUSIONS: Low GABA levels are associated with poor seizure control in patients with CPS, but not in JME. Higher homocarnosine levels are associated with better seizure control in both types of epilepsy.
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Authors | O A Petroff, F Hyder, D L Rothman, R H Mattson |
Journal | Neurology
(Neurology)
Vol. 56
Issue 6
Pg. 709-15
(Mar 27 2001)
ISSN: 0028-3878 [Print] United States |
PMID | 11274303
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- homocarnosine
- gamma-Aminobutyric Acid
- Carnosine
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Topics |
- Adult
- Aged
- Carnosine
(analogs & derivatives, analysis)
- Epilepsy, Complex Partial
(metabolism)
- Female
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Middle Aged
- Myoclonic Epilepsy, Juvenile
(metabolism)
- Time Factors
- gamma-Aminobutyric Acid
(analysis)
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