Abstract | PURPOSE: METHODS: A recurrent subfoveal choroidal neovascular membrane was surgically removed in two patients. The recurrence was identified as a classic membrane on fluorescein angiography at the foveal border of the laser scar. A net was visualized in the early venous phase of the indocyanine green angiogram, with associated late hyperfluorescence. Both patients had undergone laser photocoagulation for a classic interpapillomacular choroidal neovascular membrane about 1 1/2 years earlier. The specimens were serially sectioned and stained with hematoxylin- eosin, periodic acid-Schiff, Masson trichrome and phosphotungstic acid- hematoxylin. RESULTS: The two specimens consisted of subretinal fibrovascular tissue with fibrin exudation. Fibrovascular tissue bordered subretinal fibrous tissue adherent to Bruch's membrane and remnants of the choroid in one patient. The fibrovascular portion most likely corresponded to the recurrence, whereas the fibrous portion represented the original membrane, being obliterated after photocoagulation. Some peripapillary tissue was additionally removed in the other patient. The latter lesion was invisible on fluorescein angiography but stained in the late phase of indocyanine green angiography and corresponded histopathologically to poorly vascularized intra-Bruch's fibrovascular tissue. Granular deposits, periodic acid-Schiff positive and metachromatically purple on Masson trichrome stain, representing diffuse drusen (basal laminar/linear deposits), were identified in the three specimens. CONCLUSION:
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Authors | B A Lafaut, S Aisenbrey, C Vanden Broecke, F Di Tizio, K U Bartz-Schmidt |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 239
Issue 1
Pg. 5-11
(Jan 2001)
ISSN: 0721-832X [Print] Germany |
PMID | 11271462
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
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Topics |
- Aged
- Choroidal Neovascularization
(etiology, pathology, surgery)
- Exudates and Transudates
- Fibrosis
- Fluorescein Angiography
- Fundus Oculi
- Humans
- Indocyanine Green
- Laser Coagulation
- Macular Degeneration
(complications, pathology, surgery)
- Male
- Recurrence
- Retinal Vessels
(pathology)
- Visual Acuity
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