Recombinant granulocyte colony-stimulating factor (G-CSF) in infectious diseases: still a debate.

Abstract

Granulocyte colony-stimulating factor (G-CSF), a central mediator of the endogenous response to infection and inflammation, is approved for use in the prevention of infection-related complications in patients with nonmyeloid malignancies during antineoplastic therapy associated with high risk of severe neutropenia. Administration of granulocyte colony-stimulating factor results in improvement of host defence paired with anti-inflammatory effects. There is evidence from animal and clinical studies that administration of granulocyte colony-stimulating factor may also be beneficial in non-neutropenic infections. This review focuses mainly on the results of different animal and clinical studies of granulocyte colony stimulating factor used in the treatment of severe infections and sepsis.

• Authors: F J Wiedermann, M Mittermayr, G Hoffmann, W Schobersberger
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 113 Issue 3-4 Pg. 90-6 (Feb 15 2001) ISSN: 0043-5325 [Print] Austria
• PMID: 11253746 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Placebos
• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• Filgrastim

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Bacterial Infections (drug therapy)
• Brain Injuries (complications)
• Clinical Trials as Topic
• Disease Models, Animal
• Drug Therapy, Combination
• Filgrastim
• Granulocyte Colony-Stimulating Factor (administration & dosage, therapeutic use)
• Guinea Pigs
• Humans
• Inflammation (drug therapy)
• Mice
• Neoplasms (drug therapy)
• Neutropenia (drug therapy, etiology)
• Placebos
• Pneumonia, Bacterial (drug therapy)
• Randomized Controlled Trials as Topic
• Rats
• Recombinant Proteins
• Respiratory Distress Syndrome (complications)
• Risk Factors
• Sepsis (drug therapy, etiology)
• Sheep
• Shock, Hemorrhagic (drug therapy)
• Shock, Septic (drug therapy)
• Swine