Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.

Abstract

Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SB deficit was observed on repeated treatment with methamphetamine for 14 days. The SB deficit produced by treatment with PCP (10 mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SB in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SB deficit.

• Authors: H Qiao, Y Noda, H Kamei, T Nagai, H Furukawa, H Miura, Y Kayukawa, T Ohta, T Nabeshima
• Journal: Neuroreport (Neuroreport) Vol. 12 Issue 1 Pg. 11-5 (Jan 22 2001) ISSN: 0959-4965 [Print] England
• PMID: 11201068 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Hallucinogens
• Phencyclidine
• Clozapine
• Haloperidol

Topics

• Animals
• Antipsychotic Agents (pharmacology, therapeutic use)
• Behavior, Animal (drug effects, physiology)
• Clozapine (pharmacology, therapeutic use)
• Hallucinogens (adverse effects)
• Haloperidol (pharmacology, therapeutic use)
• Male
• Mice
• Models, Animal
• Phencyclidine (adverse effects)
• Schizophrenia (drug therapy)
• Social Behavior
• Substance Withdrawal Syndrome (drug therapy, psychology)