Abstract | OBJECTIVE: CASE REPORT: DISCUSSION: Concurrent administration of fluconazole with amitriptyline likely resulted in the decreased metabolism of amitriptytine. Three case reports presented in the literature of adults receiving concurrent amitriptyline and fluconazole have shown an increase in serum amitriptyline concentrations with concurrent administration of fluconazole; however, none of these patients were rechallenged. Literature available on amitriptyline overdose confirms that syncope and the adverse events noted in the case studies may result from elevated amitriptyline plasma concentrations. CONCLUSIONS: The consistent presentation of syncope in our patient during readministration of amitriptytine and fluconazole strongly suggests a drug-drug interaction.
|
Authors | R F Robinson, M C Nahata, R S Olshefski |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 34
Issue 12
Pg. 1406-9
(Dec 2000)
ISSN: 1060-0280 [Print] United States |
PMID | 11144697
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antidepressive Agents, Tricyclic
- Antifungal Agents
- Amitriptyline
- Fluconazole
|
Topics |
- Amitriptyline
(adverse effects)
- Antidepressive Agents, Tricyclic
(adverse effects)
- Antifungal Agents
(adverse effects)
- Child
- Drug Interactions
- Fluconazole
(adverse effects)
- Humans
- Male
- Syncope
(chemically induced)
|