Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application.

Abstract

Many studies have explored the effects of immunotherapy, alone or in combination with conventional therapies, on both experimental and human cancers. Evidence has been provided that combined treatments with thymosin alpha 1 (T alpha 1) and low doses of interferon (IFN) or interleukin (IL)-2 are highly effective in restoring several immune responses depressed by tumor growth and/or cytostatic drugs. In addition, when combined with specific chemotherapy, they are able to increase the anti-tumor effect of chemotherapy while markedly reducing the general toxicity of the treatment. The advantages of using this combined chemo-immunotherapeutic approach in experimental and human cancers are reviewed in this issue.

• Authors: E Garaci, F Pica, G Rasi, C Favalli
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 22 Issue 12 Pg. 1067-76 (Dec 2000) ISSN: 0192-0561 [Print] England
• PMID: 11137613 (Publication Type: Journal Article, Review)

Chemical References

• Adjuvants, Immunologic
• Antineoplastic Agents
• Thymosin
• Thymalfasin

Topics

• Adjuvants, Immunologic (pharmacology, therapeutic use)
• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Combined Modality Therapy
• Humans
• Immunotherapy
• Neoplasms (pathology, therapy)
• Thymalfasin
• Thymosin (analogs & derivatives, pharmacology, therapeutic use)