Neoplasia of plasma cells with atypical presentation and infection by the human immunodeficiency virus. A presentation of two cases.

Abstract

Neoplasia of plasma cells acquires special clinical characteristics in patients infected by human immunodeficiency virus (HIV). These patients are much younger at the time of diagnosis, and when they are compared with the general population they show an atypical clinical evolution, with a greater frequency of solitary plasmacytomas, less evidence of a monoclonal plasmatic component, or greater aggressiveness of the neoplastic process. This paper provides the most significant data on two patients infected by HIV and diagnosed for plasma cell neoplasia. Recent pathogenetic hypotheses for plasma cell neoplasias that include immune alterations, chronic viral infections, and hyperexpression of cytokines exist in patients infected by HIV, and this could suggest that this type of neoplasia is another malignant haematological process associated with AIDS.

• Authors: S Herranz, M Sala, M Cervantes, M Sasal, A Soler, F Segura
• Journal: American journal of hematology (Am J Hematol) Vol. 65 Issue 3 Pg. 239-42 (Nov 2000) ISSN: 0361-8609 [Print] United States
• PMID: 11074542 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Neoplasms (etiology)
• HIV Infections (complications)
• Humans
• Male
• Middle Aged
• Plasmacytoma (etiology)
• Tibia