Abstract | BACKGROUND: Moderate alcohol intake is associated with lower atherosclerosis risk, presumably due to increased HDL cholesterol (HDL-C) concentrations; however, the metabolic mechanisms of this increase are poorly understood. METHODS AND RESULTS: We tested the hypothesis that ethanol increases HDL-C by raising transport rates (TRs) of the major HDL apolipoproteins apoA-I and -II. We measured the turnover of these apolipoproteins in vivo in paired studies with and without alcohol consumption in 14 subjects. The fractional catabolic rate (FCR) and TR of radiolabeled apoA-I and -II were determined in the last 2 weeks of a 4-week Western-type metabolic diet, without (control) or with alcohol in isocaloric exchange for carbohydrates. Alcohol was given as vodka in fixed amounts ranging from 0.20 to 0.81 g. kg(-1). d(-1) (mean+/-SD 0.45+/-0.19) to reflect the usual daily intake of each subject. HDL-C concentrations increased 18% with alcohol compared with the control (Wilcoxon matched-pairs test, P=0.002). The apoA-I concentrations increased by 10% (P=0.048) and apoA-II concentrations increased by 17% (P=0.005) due to higher apoA-I and -II TRs, respectively, whereas the FCR of both apoA-I and -II did not change. The amount of alcohol consumed correlated with the degree of increase in HDL-C (Pearson's r=0.66, P=0.01) and apoA-I TR (r=0.57, P=0.03). The increase in HDL-C also correlated with the increase in apoA-I TR (r=0.61, P=0.02). CONCLUSIONS: Alcohol intake increases HDL-C in a dose-dependent fashion, associated with and possibly caused by an increase in the TR of HDL apolipoproteins apoA-I and -II.
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Authors | E R De Oliveira E Silva, D Foster, M McGee Harper, C E Seidman, J D Smith, J L Breslow, E A Brinton |
Journal | Circulation
(Circulation)
Vol. 102
Issue 19
Pg. 2347-52
(Nov 07 2000)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11067787
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoprotein A-I
- Apolipoprotein A-II
- Cholesterol, HDL
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Topics |
- Adult
- Aged
- Alcohol Drinking
(blood, metabolism)
- Apolipoprotein A-I
(blood, metabolism)
- Apolipoprotein A-II
(blood, metabolism)
- Biological Transport
- Cholesterol, HDL
(blood)
- Female
- Humans
- Male
- Middle Aged
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