Isolated pericardial effusion and transient abnormal myelopoiesis in a fetus with Down's syndrome.

Abstract

Isolated pericardial effusion was detected in a fetus at 34 weeks of gestation. A male infant weighing 2,044 g was born by cesarean section because of a non-assuring fetal heart rate pattern at 35 weeks of gestation. Transient leukocytosis (36,100/microl) with 49% blast cells was seen in this neonate. The infant's karyotype was 47, XY + 21. The pericardial effusion disappeared after treatment with prednisolone at a dose of 2 mg/kg/day. Hypothyroidism was subsequently found. Thus, the subject patient with Down's syndrome developed isolated pericardial effusion, transient abnormal myelopoiesis (TAM), and hypothyroidism. Because more than 20% of the infants with TAM and Down's syndrome develop acute nonlymphocytic leukemia in early childhood, he is being closely observed.

• Authors: C Hirashima, Y Eguchi, Y Kohmura, H Minakami, I Sato
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 26 Issue 4 Pg. 303-6 (Aug 2000) ISSN: 1341-8076 [Print] Australia
• PMID: 11049242 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Diagnosis, Differential
• Down Syndrome (complications, diagnosis, embryology)
• Female
• Fetal Diseases (diagnosis, diagnostic imaging, embryology)
• Humans
• Hypothyroidism (complications, diagnosis)
• Infant, Newborn
• Leukopoiesis
• Male
• Pericardial Effusion (complications, diagnostic imaging, embryology)
• Pregnancy
• Prenatal Diagnosis
• Ultrasonography