Abstract | OBJECTIVES: PATIENTS AND METHODS: Patients with lung cancer given palliative care and who developed anorexia with or without weight loss were given 320 mg/d megestrol acetate in 2 doses and 40 mg/d prednisolone in one dose in the morning for 1 month. The principal outcome criterion was anorexia assessed on a visual analog scale prior to treatment and then at day 15 and day 30. Variation in daily calorie intake and weight were also recorded. We used an Armitage sequential plan to determine the number of inclusions necessary and the preference method (closed schema) to evaluate the principal outcome criterion. RESULTS: Inclusions were stopped after the eighth patient (giving p<0.05) as we observed a significant improvement in patient appetite. Daily calorie intake improved significantly (p<0.0001), by 39.18% the first 15 days and 16.57% more the next 15 days. Body weight improved significantly by 5.4% in one month (p=0.5). No treatment-related complication occurred during the study period or during the six consecutive months. CONCLUSIONS:
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Authors | T Jeanfaivre, V Souday, D Chaleil, F Maillet, E Tuchais |
Journal | Revue de pneumologie clinique
(Rev Pneumol Clin)
Vol. 56
Issue 4
Pg. 255-60
(Sep 2000)
ISSN: 0761-8417 [Print] France |
Vernacular Title | Essai de phase II évaluant l'effet d'une association acétate de mégestrol et prednisolone dans le traitement de l'anorexie au cours du cancer bronchique en phase palliative. |
PMID | 11033533
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Antineoplastic Agents, Hormonal
- Prednisolone
- Megestrol Acetate
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anorexia
(drug therapy, etiology)
- Anti-Inflammatory Agents
(administration & dosage)
- Antineoplastic Agents, Hormonal
(administration & dosage)
- Data Interpretation, Statistical
- Drug Therapy, Combination
- Humans
- Lung Neoplasms
(complications, therapy)
- Male
- Megestrol Acetate
(administration & dosage)
- Middle Aged
- Palliative Care
- Prednisolone
(administration & dosage)
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