Abstract | BACKGROUND: MATERIALS AND METHODS: Six hundred and ten subjects of a general population of middle-aged and elderly subjects, 170 of whom had type 2 diabetes, participated in this cross-sectional study. Linear regression analyses were used to study whether tHcy was associated with vWf, sVCAM-1 and CRP, and whether the presence of diabetes modified these associations. RESULTS: After adjustment for confounders, tHcy was significantly but weakly associated with vWf (beta = 0.15, P = 0.05) and sVCAM-1 (beta = 0.082, P = 0.04). tHcy was not significantly associated with CRP (beta = 0.02, P = 0.91). The presence of diabetes did not significantly modify these associations. CONCLUSIONS: This study provides evidence that tHcy is, at most, weakly associated with endothelial dysfunction as estimated from plasma vWf, and with leukocyte adhesion as estimated from plasma sVCAM-1. tHcy was not significantly associated with chronic low-grade inflammation as estimated from plasma CRP. Our data thus suggest that the link between tHcy and atherothrombosis cannot be explained by associations of tHcy with vWf, sVCAM-1 or CRP.
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Authors | A Becker, V W Van Hinsbergh, P J Kostense, A Jager, J M Dekker, G Nijpels, R J Heine, L M Bouter, C D Stehouwer |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 30
Issue 9
Pg. 763-70
(Sep 2000)
ISSN: 0014-2972 [Print] England |
PMID | 10998075
(Publication Type: Journal Article)
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Chemical References |
- Cell Adhesion Molecules
- von Willebrand Factor
- Homocysteine
- C-Reactive Protein
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Topics |
- Aged
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(blood, epidemiology)
- Cell Adhesion Molecules
(blood)
- Diabetes Mellitus, Type 2
(blood, metabolism)
- Female
- Homocysteine
(blood)
- Humans
- Male
- Middle Aged
- Risk Factors
- von Willebrand Factor
(metabolism)
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