Immune reconstitution syndromes in human immuno-deficiency virus infection following effective antiretroviral therapy.

Abstract

Effective antiretroviral therapy leads to rapid decrease in plasma HIV-1 RNA, frequently followed by an increase in CD4 T-helper cell counts. The improvement of immune function during highly active antiretroviral therapy has important impact on natural history of AIDS-related opportunistic disorders. Here we describe cases of unusual clinical inflammatory syndromes in CMV retinitis, hepatitis C, and atypical mycobacteriosis in HIV-1 infected patients associated with the initiation of antiretroviral therapy. Pathogenetic implications and therapeutic management of these new immunopathologic syndromes are discussed.

• Authors: G M Behrens, D Meyer, M Stoll, R E Schmidt
• Journal: Immunobiology (Immunobiology) Vol. 202 Issue 2 Pg. 186-93 (Aug 2000) ISSN: 0171-2985 [Print] Netherlands
• PMID: 10993293 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-HIV Agents
• HIV Protease Inhibitors
• Reverse Transcriptase Inhibitors
• Lamivudine
• Zidovudine
• Indinavir

Topics

• AIDS-Related Opportunistic Infections (complications, drug therapy, immunology, virology)
• Acquired Immunodeficiency Syndrome (drug therapy, immunology, virology)
• Adult
• Anti-HIV Agents (therapeutic use)
• Antiretroviral Therapy, Highly Active
• Cytomegalovirus Retinitis (complications, immunology)
• Female
• HIV Protease Inhibitors (therapeutic use)
• HIV-1 (genetics, immunology)
• Hepatitis C (complications, immunology)
• Humans
• Indinavir (therapeutic use)
• Lamivudine (therapeutic use)
• Male
• Middle Aged
• Mycobacterium avium-intracellulare Infection (complications, immunology)
• Reverse Transcriptase Inhibitors (therapeutic use)
• Zidovudine (therapeutic use)