Efficacy of ampicillin plus arbekacin in experimental rabbit endocarditis caused by an Enterococcus faecalis strain with high-level gentamicin resistance.

Abstract

Enterococcus faecalis LC40 is an ampicillin-susceptible clinical isolate with high-level gentamicin resistance due to the aac(6')-Ie-aph(2")-Ia aminoglycoside resistance gene. The combination of ampicillin plus arbekacin reduced mean bacterial vegetation counts significantly more than ampicillin alone or ampicillin plus gentamicin in a rabbit model of aortic-valve endocarditis caused by E. faecalis LC40.

• Authors: V Kak, S M Donabedian, M J Zervos, R Kariyama, H Kumon, J W Chow
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 44 Issue 9 Pg. 2545-6 (Sep 2000) ISSN: 0066-4804 [Print] United States
• PMID: 10952613 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• Gentamicins
• Dibekacin
• Ampicillin
• arbekacin

Topics

• Aminoglycosides
• Ampicillin (therapeutic use)
• Animals
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Dibekacin (analogs & derivatives, therapeutic use)
• Disease Models, Animal
• Drug Resistance, Microbial (physiology)
• Drug Therapy, Combination (therapeutic use)
• Endocarditis, Bacterial (drug therapy, microbiology)
• Enterococcus faecalis (drug effects)
• Gentamicins (pharmacology)
• Gram-Positive Bacterial Infections (drug therapy, microbiology)
• Microbial Sensitivity Tests
• Rabbits
• Treatment Outcome