Abstract | BACKGROUND: METHODS: RESULTS: Recurrent venous thromboembolism developed in 38 of the 360 patients (10.6 percent). Patients with recurrence had higher mean (+/-SD) plasma levels of factor VIII than those without recurrence (182+/-66 vs. 157+/-54 IU per deciliter, P=0.009). The relative risk of recurrent venous thrombosis was 1.08 (95 percent confidence interval, 1.04 to 1.12; P<0.001) for each increase of 10 IU per deciliter in the plasma level of factor VIII. Among patients with a factor VIII level above the 90th percentile of the values in the study population, the likelihood of recurrence at two years was 37 percent, as compared with a 5 percent likelihood among patients with lower levels (P<0.001). Among patients with plasma factor VIII levels above the 90th percentile, as compared with those with lower levels, the overall relative risk of recurrence was 6.7 (95 percent confidence interval, 3.0 to 14.8) after adjustment for age, sex, the presence or absence of factor V Leiden or the G20210A prothrombin mutation, and the duration of oral anticoagulation. CONCLUSIONS:
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Authors | P A Kyrle, E Minar, M Hirschl, C Bialonczyk, M Stain, B Schneider, A Weltermann, W Speiser, K Lechner, S Eichinger |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 343
Issue 7
Pg. 457-62
(Aug 17 2000)
ISSN: 0028-4793 [Print] United States |
PMID | 10950667
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Factor VIII
(analysis)
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Pulmonary Embolism
(blood)
- Recurrence
- Risk
- Risk Factors
- Venous Thrombosis
(blood)
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