Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation.

Abstract

BACKGROUND:

Acute graft-versus-host disease still represents the major factor that limits successful allogeneic bone marrow transplantation. Cytokines released by type 1 T-helper cells are thought to play a pivotal role in acute graft-versus-host disease.

OBJECTIVE:

This study was performed to investigate whether the serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma were associated with the manifestation of acute graft-versus-host disease.

METHODS:

Serum cytokine levels were measured by sandwich ELISA in 18 patients who underwent allogeneic bone marrow transplantation.

RESULTS:

Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma were increased in patients in whom acute graft-versus-host disease developed. However, only serum soluble IL-2 receptor levels were significantly related to disease severity. Serum levels of IL-12 and IL-18, both of which are mainly produced by activated macrophages, were increased in different phases of acute graft-versus-host disease, especially grade I. Serum levels of soluble IL-2 receptor and IFN-gamma were significantly elevated in patients with fever.

CONCLUSION:

Serum levels of soluble IL-2 receptor were more closely related to the severity of acute graft-versus-host disease than those of IL-12, IL-18, and IFN-gamma.

• Authors: H Nakamura, K Komatsu, M Ayaki, S Kawamoto, M Murakami, N Uoshima, T Yagi, T Hasegawa, M Yasumi, T Karasuno, H Teshima, A Hiraoka, T Masaoka
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 106 Issue 1 Pt 2 Pg. S45-50 (Jul 2000) ISSN: 0091-6749 [Print] United States
• PMID: 10887333 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Interleukin-18
• Receptors, Interleukin-2
• Interleukin-12
• Interferon-gamma

Topics

• Acute Disease
• Adolescent
• Adult
• Bone Marrow Transplantation (adverse effects)
• Cytokines (blood)
• Female
• Fever (blood)
• Graft vs Host Disease (blood, etiology)
• Humans
• Interferon-gamma (blood)
• Interleukin-12 (blood)
• Interleukin-18 (blood)
• Male
• Receptors, Interleukin-2 (blood)
• Solubility
• Th1 Cells (metabolism)