Postprandial response to a fat tolerance test in young adults with a paternal history of premature coronary heart disease - the EARS II study (European Atherosclerosis Research Study).

Abstract

BACKGROUND:

The European Atherosclerosis Research Study (EARS) I had shown that fasting plasma concentrations of apolipoprotein B (apo B) and triglycerides were the most discriminant variables between offspring with a paternal history of coronary heart disease (CHD) and controls. The EARS II study was undertaken to investigate whether a paternal history of CHD was associated with differences in postprandial lipemia.

DESIGN:

Male subjects with a paternal history of CHD (cases, n = 407) and age-matched male controls (n = 415) were recruited from 14 European universities. All subjects had an oral fat tolerance test.

RESULTS:

In the sample as a whole, the postprandial triglyceride responses did not significantly differ between the two groups. However, in the upper tertile of fasting triglycerides, cases displayed a higher area under the curve (5.71 vs. 4.49 mmol.h L-1, P < 0.001), a higher peak (1.76 vs. 1.43 mmol L-1, P < 0.001) and a more delayed time to peak (3.15 vs. 2.91 h, P < 0.05) than controls. In the upper tertile, fasting apo B levels (P < 0.05) and triglyceride area under the curve (P = 0.002) significantly discriminated cases from controls in a multivariate analysis. Cases had also higher Lp C-III:B levels at 4 h than controls (11.2 vs. 9.9 mg dL-1, P < 0.01) and this difference remained significant after adjustment for apo B and triglyceride levels.

CONCLUSIONS:

These results indicate that in subjects with a moderate elevation of fasting triglycerides, an impaired postprandial response to a fat load constitutes an early biological expression of a paternal history of premature CHD.

• Authors: L Tiret, C Gerdes, M J Murphy, J Dallongeville, V Nicaud, D S O'Reilly, U Beisiegel, G De Backer
• Journal: European journal of clinical investigation (Eur J Clin Invest) Vol. 30 Issue 7 Pg. 578-85 (Jul 2000) ISSN: 0014-2972 [Print] England
• PMID: 10886297 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Apolipoprotein C-III
• Apolipoproteins B
• Apolipoproteins C
• Apolipoproteins E
• Cholesterol, HDL
• Cholesterol, LDL
• Dietary Fats
• Triglycerides

Topics

• Administration, Oral
• Adolescent
• Adult
• Apolipoprotein C-III
• Apolipoproteins B (blood)
• Apolipoproteins C (blood)
• Apolipoproteins E (blood)
• Case-Control Studies
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Artery Disease (diagnosis, genetics)
• Coronary Disease (diagnosis, genetics)
• Dietary Fats (administration & dosage, blood)
• Family Health
• Fathers
• Genetic Predisposition to Disease
• Humans
• Logistic Models
• Male
• Postprandial Period
• Predictive Value of Tests
• Triglycerides (blood)