Abstract | AIM: METHODS: RESULTS: Western and dot blotting showed anti-CA II antibodies in all and anti- Enolase antibodies in six of the 10 patients. The average titer measured with ELISA was 0.9 +/- 0.08 OD Units (0.35-1.4) with a dilution of 1:400. CONCLUSION: The presence of anti- retinal antibodies in the serum of all patients confirms the high prevalence of these antibodies in patients with CME. This may suggest that a dysfunction of CA and enolase activity in the retinal pigment epithelium may lie at the root of oedema formation, whereas other mechanisms may be responsible in the absence of these antibodies.
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Authors | T J Wolfensberger, N Aptsiauri, B Godley, S Downes, A C Bird |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 216
Issue 5
Pg. 283-5
(May 2000)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | Antiretinale Antikörper assoziiert mit zystoidem Makulaödem. |
PMID | 10863693
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Carbonic Anhydrases
- Phosphopyruvate Hydratase
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Topics |
- Adult
- Autoantibodies
(immunology)
- Blotting, Western
- Carbonic Anhydrases
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoblotting
- Macular Edema
(etiology, immunology)
- Male
- Phosphopyruvate Hydratase
(immunology)
- Retina
(enzymology, immunology)
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