Effects of ovariectomy on parafollicular cells in the rat.

Abstract	Changes in the parafollicular cells in the thyroid gland of ovariectomized rats were investigated to clarify the relationship between the secretory function of sex hormones and that of parafollicular cells. Compared with control rats, the ovariectomized rats exhibited decreases in 1) the number of parafollicular cells in the thyroid glands, 2) the number of secretory granules in the parafollicular cells, and 3) the area occupied by the Golgi complex. These results suggest that the lack of estrogen caused by ovariectomy reduces the synthesis and release of calcitonin in parafollicular cells, which may be one of the causes of osteoporosis.
Authors	K Sakai, S Yamada, K Yamada
Journal	Okajimas folia anatomica Japonica (Okajimas Folia Anat Jpn) Vol. 76 Issue 6 Pg. 311-9 (Mar 2000) ISSN: 0030-154X [Print] Japan
PMID	10774229 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Calcitonin Calcium
Topics	Animals Body Weight Calcitonin (analysis) Calcium (blood) Cell Count Cell Nucleus (ultrastructure) Cytoplasm (ultrastructure) Cytoplasmic Granules (ultrastructure) Female Golgi Apparatus (ultrastructure) Image Processing, Computer-Assisted Ovariectomy Rats Thyroid Gland (chemistry, cytology, physiology)

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