Effect of intravenous fructose 1,6-diphosphate administration in malnourished chronic obstructive pulmonary disease patients with chronic respiratory failure.

Abstract

BACKGROUND:

Weight loss and skeletal muscle wasting are common in patients with chronic obstructive pulmonary disease (COPD) and can influence the course and the prognosis of COPD. Hypophosphatemia is a pathologic status often characterized by muscle weakness and is a frequent laboratory finding in these patients.

OBJECTIVE:

The aim of the present study was to evaluate the effect of an organic phosphate (fructose 1,6-diphosphate, FDP) administration on respiratory performance in 45 malnourished COPD patients in stable clinical conditions.

METHODS:

Physiologic evaluation including spirometry, maximal voluntary ventilation (MMV), elevated arm test, maximal mouth pressures (PImax and PEmax), respiratory response to CO(2), oxygen (PaO(2)) and carbon dioxide (PaCO(2)) arterial tension, a visual analogic scale (VAS) to measure dyspnea, and complete blood tests were done at the beginning and again at the end of the study.

RESULTS:

After FDP administration, there was a significant increase in PImax (43.0 +/- 18.3 cm H(2)O before treatment vs. 49.8 +/- 14.9 cm H(2)O after treatment; p < 0.005). This did not occur in the placebo group (40.3 +/- 17.4 cm H(2)O before treatment vs. 42.6 +/- 20.1 cm H(2)O after treatment, nonsignificant). There was also a trend of VAS to decrease and of MVV to increase.

CONCLUSIONS:

These results show that FDP administration may be useful in the management of malnourished COPD patients, especially in increasing their respiratory muscle strength.

• Authors: F Marchesani, G Valerio, N Dardes, B Viglianti, C M Sanguinetti
• Journal: Respiration; international review of thoracic diseases (Respiration) Vol. 67 Issue 2 Pg. 177-82 ( 2000) ISSN: 0025-7931 [Print] Switzerland
• PMID: 10773790 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright 2000 S. Karger AG, Basel

Chemical References

• Chlorides
• Fructosediphosphates
• Phosphorus
• fructose-1,6-diphosphate
• Potassium

Topics

• Aged
• Blood Gas Analysis
• Body Height (drug effects)
• Body Weight (drug effects)
• Chlorides (blood)
• Cross-Over Studies
• Eating
• Female
• Fructosediphosphates (administration & dosage)
• Humans
• Infusions, Intravenous
• Lung Diseases, Obstructive (blood, complications)
• Male
• Middle Aged
• Nutrition Disorders (blood, complications, drug therapy)
• Phosphorus (blood)
• Potassium (blood)
• Respiration (drug effects)
• Respiratory Function Tests
• Respiratory Insufficiency (blood, complications, physiopathology)
• Treatment Outcome