Abstract | BACKGROUND: METHODS: Plasma levels of TNF-alpha and its soluble receptors (sTNF-RI, sTNF-RII) and of soluble vascular cell adhesion molecule 1 (sVCAM-1) were monitored over the 6 months postgraft period when PTX or placebo were administered. Expression of VCAM-1 and intercellular cell adhesion molecule 1 was scored by immunohistochemical staining of biopsy specimens from patients who underwent rejection crisis. Lymphocyte subset composition was analyzed longitudinally during cytomegalovirus (CMV) infections. RESULTS: Plasma TNF-alpha levels were significantly reduced in the PTX-treated group over the 6 months of administration, and specifically during isolated rejection episodes and during CMV infections. Plasma levels of sTNFR-I, sTNFR-II, and sVCAM-1 did not differ between the two groups of patients, but a decrease in renal tubular VCAM-1 expression was observed in the PTX group. During CMV infections, CD8 lymphocytosis and expansion of CD57+ (CD28-) CD8+ T cells were similar in the two groups. CONCLUSION: The data collected during this double-blind study point to an immunomodulatory role of PTX, the beneficial effect on graft survival resulting from a restraining effect of the drug on the inflammatory conditions involved in acute graft rejection.
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Authors | C Noel, M C Copin, M Hazzan, M Labalette, S Susen, G Lelievre, J P Dessaint |
Journal | Transplantation
(Transplantation)
Vol. 69
Issue 6
Pg. 1102-7
(Mar 27 2000)
ISSN: 0041-1337 [Print] United States |
PMID | 10762214
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- CD68 antigen, human
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tumor Necrosis Factor-alpha
- Vascular Cell Adhesion Molecule-1
- Intercellular Adhesion Molecule-1
- Pentoxifylline
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Topics |
- Adjuvants, Immunologic
(pharmacology)
- Antigens, CD
(blood)
- Antigens, Differentiation, Myelomonocytic
(blood)
- Biopsy
- CD4-Positive T-Lymphocytes
(pathology)
- CD8-Positive T-Lymphocytes
(pathology)
- Cadaver
- Cytomegalovirus Infections
(blood, genetics)
- Double-Blind Method
- Graft Rejection
(prevention & control)
- Humans
- Intercellular Adhesion Molecule-1
(blood)
- Kidney Transplantation
(immunology, pathology)
- Lymphocytes
(metabolism)
- Pentoxifylline
(pharmacology)
- Phenotype
- Receptors, Tumor Necrosis Factor
(blood)
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Solubility
- T-Lymphocytes
(immunology, pathology)
- Transplantation, Homologous
(immunology, pathology)
- Tumor Necrosis Factor-alpha
(analysis, drug effects)
- Vascular Cell Adhesion Molecule-1
(blood)
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