Clinical evaluation of the effect of a remineralizing toothpaste on dentinal sensitivity.

Abstract

Dentinal hypersensitivity is a common dental problem without a satisfactory solution. Most therapies have focused on either trying to block the stimulation of dentinal nerves or on sealing open dentinal tubules. This study evaluated, in a double blind clinical trial, the effect of Enamelon, a dentifrice containing sodium fluoride, calcium salts and phosphate salts (calcium separated from the phosphate and fluoride by a plastic divider in the tube to prevent interaction) on dentinal hypersensitivity over an 8-week period. A conventional OTC dentifrice containing NaF without calcium and phosphate enhancement served as the control. A third dentifrice, containing sodium monofluorophosphate enhanced by calcium and phosphate salts, was also tested. Based upon subjective anecdotal information, net numbers of sensitive teeth which became non-sensitive, and a logit analysis of the change in the proportion of sensitive teeth over the study time period, Enamelon was the most effective product, and the OTC control the least effective.

• Authors: H W Kaufman, M S Wolff, A E Winston, C W Triol
• Journal: The Journal of clinical dentistry (J Clin Dent) Vol. 10 Issue 1 Spec No Pg. 50-4 ( 1999) ISSN: 0895-8831 [Print] United States
• PMID: 10686861 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Calcium Phosphates
• Dentifrices
• Enamelon
• Phosphates
• fluorophosphate
• Fluorides
• Calcium

Topics

• Analysis of Variance
• Calcium
• Calcium Phosphates (chemistry, therapeutic use)
• Chi-Square Distribution
• Dentifrices (chemistry, therapeutic use)
• Dentin Sensitivity (prevention & control)
• Double-Blind Method
• Female
• Fluorides (chemistry, therapeutic use)
• Humans
• Logistic Models
• Male
• Phosphates (therapeutic use)
• Statistics, Nonparametric