Abstract |
In recent years, bronchial asthma has come to be regarded pathologically as a chronic inflammatory disease of the respiratory tract. Inhalational steroids and antiinflammatory drugs are recognized as being effective against bronchial asthma. In this study, the effects of Saiboku-to, a Chinese herbal ( Kampo) formulation, were investigated on asthmatic guinea pigs sensitized to ovalbumin (OA). Following 7-day administration of Saiboku-to (500 micrograms/kg), the late asthmatic response (LAR) to an antigen challenge was found to be inhibited. The number of eosinophils in fluid obtained by bronchoalveolar lavage (BAL) 4 h after antigen challenge was decreased while the infiltration of eosinophils and T-lymphocytes into the lung parenchyma was inhibited. These findings suggest that Saiboku-to has the potential to become a useful drug in the treatment of bronchial asthma.
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Authors | Y Tohda, R Haraguchi, H Kubo, M Muraki, M Fukuoka, S Nakajima |
Journal | Methods and findings in experimental and clinical pharmacology
(Methods Find Exp Clin Pharmacol)
1999 Jul-Aug
Vol. 21
Issue 6
Pg. 449-52
ISSN: 0379-0355 [Print] Spain |
PMID | 10445239
(Publication Type: Journal Article)
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Chemical References |
- Antigens
- Bronchodilator Agents
- Drugs, Chinese Herbal
- Ovalbumin
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Topics |
- Animals
- Antigens
(administration & dosage)
- Asthma
(drug therapy, immunology, pathology, physiopathology)
- Bronchoconstriction
(drug effects, immunology)
- Bronchodilator Agents
(pharmacology)
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology)
- Guinea Pigs
- Male
- Medicine, Chinese Traditional
- Ovalbumin
(administration & dosage)
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