Leucine-tRNA Ligase

An enzyme that activates leucine with its specific transfer RNA. EC 6.1.1.4.

Also Known As:

Leu-tRNA Ligase; Leucine-tRNA Synthetase; Leu tRNA Ligase; Leucine tRNA Ligase; Leucine tRNA Synthetase; Ligase, Leu-tRNA; Ligase, Leucine-tRNA; Synthetase, Leucine-tRNA; Leucyl T RNA Synthetase; L-Leucine:tRNA(Leu) ligase (AMP-forming)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        Leucine-tRNA Ligase: 2
        human LARS1 protein
        mouse LARS protein
        mouse Lars2 protein

Experts

1.	Dubus, Jean-Christophe: 1 article (11/2021)
2.	Fabre, Alexandre: 1 article (11/2021)
3.	Hadchouel, Alice: 1 article (11/2021)
4.	Heux, Pauline: 1 article (11/2021)
5.	Hoebeke, Celia: 1 article (11/2021)
6.	Juzaud, Marine: 1 article (11/2021)
7.	La Fay, Charlotte: 1 article (11/2021)
8.	Spraul, Anne: 1 article (11/2021)
9.	Bishop, Juliet: 1 article (01/2019)
10.	Britton, Jacquelyn: 1 article (01/2019)

Related Diseases

1.	Liver Failure 01/01/2019 - "Deleterious mutations in cytosolic leucine-tRNA synthetase (LARS) cause infantile liver failure syndrome, type 1 (ILFS1), a recently recognized, rare autosomal recessive disorder (OMIM151350). " 01/01/2019 - "Severe Neonatal Manifestations of Infantile Liver Failure Syndrome Type 1 Caused by Cytosolic Leucine-tRNA Synthetase Deficiency." 11/01/2021 - "Pulmonary alveolar proteinosis can be caused by mutation in the methionyl-tRNA synthetase (MARS) gene while mutations in the leucine-tRNA synthetase (LARS) gene lead to infantile liver failure syndrome type 1. We report the case of a patient with LARS1 pathogenics variants and two patients with MARS1 pathogenics variants. "
2.	Pulmonary Alveolar Proteinosis 11/01/2021 - "Pulmonary alveolar proteinosis can be caused by mutation in the methionyl-tRNA synthetase (MARS) gene while mutations in the leucine-tRNA synthetase (LARS) gene lead to infantile liver failure syndrome type 1. We report the case of a patient with LARS1 pathogenics variants and two patients with MARS1 pathogenics variants. "

Related Drugs and Biologics

1.	Methionine-tRNA Ligase