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Trypan Blue

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A diazo-naphthalene sulfonate that is widely used as a stain.

Also Known As:

D.O.R.C. International Brand of Trypan Blue; Diamine Blue; Niagara Blue; VisionBlue; Blue, Diamine; Blue, Niagara; Blue, Trypan; 2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(5-amino-4-hydroxy-), tetrasodium salt

Networked: 972 relevant articles (28 outcomes, 63 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Meyer, Carsten H: 5 articles (11/2009 - 01/2004)
2.	Rodrigues, Eduardo B: 5 articles (09/2009 - 01/2004)
3.	Das, Anindita: 4 articles (05/2015 - 04/2005)
4.	Kukreja, Rakesh C: 4 articles (05/2015 - 04/2005)
5.	Raghavan, Sathees C: 4 articles (04/2015 - 08/2009)
6.	Diaz, Roberto J: 4 articles (06/2014 - 08/2002)
7.	Wilson, Gregory J: 4 articles (06/2014 - 08/2002)
8.	Baradaran, Behzad: 4 articles (01/2014 - 01/2013)
9.	Farah, Michel Eid: 4 articles (11/2009 - 02/2006)
10.	Maia, Maurício: 4 articles (11/2009 - 02/2006)

Related Diseases

1.	Cataract (Cataracts) 05/01/2004 - "Cataract surgery using trypan blue was safe and effective in managing white cataracts." 09/01/2005 - "To assess the safety and efficacy of Manual Small Incision Cataract Surgery (MSICS) in cases of white cataract with the use of trypan blue as an adjunct for performing continuous curvilinear capsulorthexis (CCC). " 06/01/2009 - "The purpose of the study was to evaluate the effect of trypan blue on intraocular pressure (IOP) after small-incision cataract surgery. " 09/01/2005 - "Prospective observational study on 100 consecutive eyes of 100 patients with white cataract who had undergone MSICS with trypan blue assisted CCC. " 03/01/2001 - "Twenty patients with mature cataract were enrolled in the study and opereted on after injection of trypan blue in the anterior chamber. "
2.	Neoplasms (Cancer) 01/01/2011 - "MTT assay and the trypan blue exclusion method were used for the in vitro study, while tumor size and the SUV of the 18FDG-PET scans were measured in animal models. " 12/08/2008 - "MTT and Trypan blue exclusion assay as well as tumorigenesis study were used to assess the anti-tumor effect in vitro and in vivo. " 02/01/2004 - "In the cancer study, the complexes Ru1-Ru4, Ru10 and Ru11 have remarkably decreased the tumor volume and viable ascitic cell count as indicated by trypan blue dye exclusion test (p<0.05). " 10/01/1985 - "Trypan blue studies indicated that less than 1% of the cells frozen to -35 degrees C were considered viable, yet significant tumor take rates were noted, suggesting that for some cells the cryoinjury is reversible. " 08/01/2015 - "Additionally, the apoptotic effect of synthesized nanoparticles on normal and cancer cells was studied using trypan blue assay and flow-cytometric analysis. "
3.	Epiretinal Membrane (Epiretinal Membranes) 06/01/2011 - "The purpose of this study was to evaluate "in vivo" safety of trypan blue (TB) in patients undergoing TB-assisted internal limiting membrane or epiretinal membrane peeling. " 04/01/2010 - "The purpose of this study was to correlate the ultrastructural morphology of epiretinal tissue with optical coherence tomography and to investigate the effects of trypan blue staining on epiretinal membrane (ERM) ultrastructure and clinical outcome. " 02/01/2005 - "[Ultrastructural study of epiretinal membrane stained by trypan blue: 15 case reports]." 04/01/2014 - "Trypan blue stains epiretinal membranes and facilitates their complete removal. " 04/01/2013 - "To evaluate the selectivity and strength of intraoperative trypan blue staining during removal of epiretinal membranes (ERMs) and the internal limiting membrane. "
4.	Anoxia (Hypoxia) 04/01/2014 - "The increase multiples of the adherent trypan blue-resistant cells cultured in normoxia with serum, in normoxia without serum, in hypoxia with serum and hypoxia in the absence of serum were 4.05 ± 0.73, 1.77 ± 0.48, 5.80 ± 0.65 and 3.69 ± 0.85 respectively, and the estimated protein contents per 10(8) cells were 463.48 ± 138.74 µg, 1604.07 ± 445.28 µg, 2389.64 ± 476.75 µg and 3141.18 ± 353.01 µg. " 03/01/2014 - "The preconditioning was proved by trypan blue cell counts following 5 h of hypoxia and confirmed by fluorescence staining. " 10/01/2005 - "After being challenged by hypoxia followed by reoxygenation, trypan blue exclusion rate was greater, cell count and cell viability were lower, and the activity of LDH was increased. " 12/01/2004 - "At 24 h following hypoxia, LDH release, trypan blue uptake, and morphologic changes were assessed. " 10/01/2003 - "Cell growth was evaluated by Trypan blue exclusion under chronic hypoxia (3-5% O2) for 4 weeks or under normal conditions (21% O2). "
5.	Necrosis 10/01/1995 - "No apoptosis was seen, and trypan blue studies confirmed that cell death by necrosis did not occur. " 06/15/2014 - "These interventions were done before cardiomyocytes were subjected to either 60- or 75-min SI/60-min SR to assess cell necrosis (by trypan blue staining), 30-min SI to assess ischemic cell swelling, or 30-min hypoosmotic (200 mosM) stress to assess cell volume regulation. " 10/01/2012 - "The cytotoxicity was evaluated by the colony forming assay, apoptosis and necrosis assay, Trypan blue exclusion dye method and mitotic index. " 06/15/2012 - "The MCF-7 cells were treated with different concentrations of GNP-Chl conjugates, and the cell viability was assayed using trypan blue, resulting in an IC(50) value of 30 ± 5 μg/mL. Flow cytometry analysis revealed that the major pathway of cell death was necrosis, which was mediated by autophagy. " 01/01/2012 - "Necrosis was determined using trypan blue exclusion and LDH release assay and apoptosis was assessed by TUNEL assay after 1 h or 18 h of reoxygenation, respectively. "

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Related Therapies and Procedures

1.	Phacoemulsification
2.	Vitrectomy
3.	Capsulorhexis
4.	Vitreoretinal Surgery
5.	Intravenous Injections