Smoothened Receptor

A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.

Also Known As:

Networked: 52 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stevens, Raymond C: 2 articles (01/2019 - 07/2014)
2.	Kelleher, Fergal C: 2 articles (01/2012 - 04/2011)
3.	Chen, Weihui: 1 article (05/2022)
4.	Guo, Yan: 1 article (05/2022)
5.	Wu, Di: 1 article (05/2022)
6.	Xu, QingJiang: 1 article (05/2022)
7.	Duan, Renjie: 1 article (02/2022)
8.	Gu, Wenjie: 1 article (02/2022)
9.	Hong, Jiao: 1 article (02/2022)
10.	Huang, Haoyu: 1 article (02/2022)

Related Diseases

1.	Basal Cell Carcinoma (Rodent Ulcer) 01/01/2018 - "Small-molecule inhibitors of the Hedgehog (HH) pathway receptor Smoothened (SMO) have been effective in treating some patients with basal cell carcinoma (BCC), where the HH pathway is often activated, but many patients respond poorly. " 01/01/2019 - "The smoothened receptor (Smo) plays a key role in Hedgehog (Hh) signaling pathway and it has been regarded as an efficacious therapeutic target for basal cell carcinoma (BCC) and medulloblastoma (MB). " 06/01/2020 - "Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects." 03/01/2020 - "Vismodegib is an effective antagonist of smoothened receptors for treatment of locally advanced or metastatic basal cell carcinoma. " 05/01/2017 - "GDC-0449, an antagonist of the hedgehog signaling receptor Smoothened (Smo), was recently approved by the US Food and Drug Administration as a prescription for skin basal cell carcinoma. "
2.	Neoplasms (Cancer) 12/01/2020 - "Inactivation of smoothened protein (SMO) by the antagonists in SHH-driven cancer types is essential for inhibition of cancer progression. " 03/28/2017 - "BACKGROUND The Hedgehog pathway receptor smoothened (SMO) has critical roles in tumor progression. " 08/01/2012 - "Here we shall review the current situation with respect to targeting the Hh pathway in cancer in general and in chemotolerance in particular with a focus on the problems associated with the emergence of tumors resistant to treatment with inhibitors targeting the Hh receptor Smoothened (SMO)." 02/01/2011 - "In vitro analyses revealed that osteolytic tumor cells lack expression of the Hh receptor, Smoothened, suggesting an Hh-independent mechanism of Gli2 regulation. " 10/08/2009 - "Lyve-1+ vessels and stromal fibroblasts in tumors expressed primary cilium and showed localization of the receptor Smoothened to the primary cilium, providing evidence of active SHH signaling through this pathway. "
3.	Brain Injuries (Brain Injury) 10/23/2014 - "A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury." 01/01/2016 - "The present study was undertaken to evaluate the influence of an agonist of the Shh co-receptor Smoothened (Smo), purmorphamine (PUR), on early brain injury (EBI) as well as the underlying mechanisms after SAH. " 01/01/2016 - "Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats."
4.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2012 - "The goal of this study was to determine the effects of antagonizing the hedgehog receptor, Smoothened (Smo), on chemotherapy response in ovarian cancer. "
5.	Glioma (Gliomas) 01/23/2020 - "The self-renewal of CSC is regulated by the SHH/Smoothened receptor (SMO)/Glioma-associated oncogene homolog I (GLI) signaling pathway. " 10/09/2019 - "A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1) has been designed and developed. " 01/01/2019 - "The most important mechanism of ITZ in the treatment of cancer is inhibition of the Hh pathway through the inhibition of smoothened receptors (SMO), glioma-associated oncogene homologs (GLI), and their downstream targets. " 01/01/2021 - "We studied the expression of SHH and components of respective signaling cascade [PTCH receptor (Patched), SMO co-receptor (Smoothened) and downstream transcriptional factor Glioma-associated oncogene (GLI)] during early abstinence in brain regions of rats demonstrating different drinking patterns in intermittent access two-bottle choice paradigm (IA2BC). " 01/01/2022 - "Currently, two main components of the pathway, the smoothened receptor and the glioma-associated oncogene homolog transcriptional factors, have been investigated for the development of targeted drugs, leading to the marketing authorization of three smoothened receptor inhibitors for the treatment of basal cell carcinoma and acute myeloid leukemia.The"

Related Drugs and Biologics

1.	HhAntag691
2.	purmorphamine
3.	serpentine (alkaloid)
4.	Proteins (Proteins, Gene)
5.	Patched Receptors
6.	sonidegib
7.	Neuroprotective Agents
8.	Transcription Factors (Transcription Factor)
9.	Patched-1 Receptor
10.	cyclopamine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics