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6H- 6- imino- (2,3,4,5- tetrahydropyrimido)(1,2- c)- (1,3)benzothiazine

inhibits dimethylarginine dimethylaminohydrolase; structure in first source

Also Known As:

3,4-dihydro-2H,6H-pyrimido(1,2-c)(1,3)benzothiazin-6-imine; PD 404,182; PD 404182

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Imines: 310
  - 6H-6-imino-(2,3,4,5-tetrahydropyrimido)(1,2-c)-(1,3)benzothiazine: 6
- Sulfur Compounds: 278
  - Thiazines: 3
    - 6H-6-imino-(2,3,4,5-tetrahydropyrimido)(1,2-c)-(1,3)benzothiazine: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - 6H-6-imino-(2,3,4,5-tetrahydropyrimido)(1,2-c)-(1,3)benzothiazine: 6

Experts

1.	Fujii, Nobutaka: 4 articles (04/2015 - 09/2012)
2.	Matsuoka, Masao: 4 articles (04/2015 - 09/2012)
3.	Mizuhara, Tsukasa: 4 articles (04/2015 - 09/2012)
4.	Ohno, Hiroaki: 4 articles (04/2015 - 09/2012)
5.	Oishi, Shinya: 4 articles (04/2015 - 09/2012)
6.	Shimura, Kazuya: 4 articles (04/2015 - 09/2012)
7.	Murayama, Hiroto: 2 articles (04/2015 - 04/2015)
8.	Okazaki, Shiho: 2 articles (04/2015 - 04/2015)
9.	Cooke, John P: 1 article (01/2014)
10.	Erlanson, Daniel A: 1 article (01/2014)

Related Diseases

1.	Infections 11/01/2012 - "3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) is an antiretroviral agent with submicromolar inhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. " 04/28/2015 - "3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) and 3,4-dihydro-2H-benzo[4,5]isothiazolo[2,3-a]pyrimidine are the heterocyclic antiretroviral agents against human immunodeficiency virus type 1 (HIV-1) infection. " 04/01/2015 - "3,4-Dihydro-2H-benzo[4,5]isothiazolo[2,3-a]pyrimidine is a newly identified antiviral agent against human immunodeficiency virus type 1 (HIV-1) infection, derived from 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182). "
2.	Virus Diseases (Viral Diseases) 09/07/2012 - "In addition, we demonstrated that the PD 404182 derivative exerts anti-HIV effects at an early stage of viral infection."
3.	Septic Shock (Toxic Shock Syndrome) 01/01/2014 - "Moreover, PD 404182 significantly increased intracellular levels of ADMA in cultured primary human vascular endothelial cells (ECs) and reduced lipopolysaccharide-induced NO production in these cells, suggesting its therapeutic potential in septic shock-induced vascular collapse. "
4.	Dengue (Dengue Fever) 02/01/2012 - "The virucidal activity of PD 404,182 appears to be virus specific, as little to no viral inactivation was detected with the enveloped Dengue and Sindbis viruses. "

Related Drugs and Biologics

1.	Imines
2.	Anti-Retroviral Agents (Antiretroviral Agents)
3.	pyrimidine
4.	Lipopolysaccharides
5.	Antiviral Agents (Antivirals)