3-acetyl-5-methyltetronic acid

vitamin K1 2,3-epoxide reductase (VKOR) inhibitor that reduces experimental glomerulonephritis

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Glomerulonephritis 07/01/2012 - "A novel vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, reduces experimental glomerulonephritis." 09/12/2017 - "We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats. "
2.	Fibrosis (Cirrhosis) 09/12/2017 - "Pharmacological effects of a vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, on cisplatin-induced fibrosis in rats." 09/12/2017 - "We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats. "

1.	Oxidoreductases (Dehydrogenase)
2.	vitamin K1 oxide
3.	Vitamin K
4.	Cisplatin (Platino)
5.	anti-Thy antibody