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N- (1- cyanocyclopropyl)- 2- (6- methoxy- 1,3,4,5- tetrahydropyrido(4,3- b)indole- 2- carbonyl)cyclohexanecarboxamide

used to treat osteoarthritis; structure in first source

Also Known As:

AZD4996

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido(4,3-b)indole-2-carbonyl)cyclohexanecarboxamide: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido(4,3-b)indole-2-carbonyl)cyclohexanecarboxamide: 1
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido(4,3-b)indole-2-carbonyl)cyclohexanecarboxamide: 1

Experts

1.	Beeley, Howard: 1 article (07/2012)
2.	Bowyer, Jonathan: 1 article (07/2012)
3.	Cook, Calum R: 1 article (07/2012)
4.	Crawford, James J: 1 article (07/2012)
5.	Dossetter, Alexander G: 1 article (07/2012)
6.	Finlayson, Jonathan E: 1 article (07/2012)
7.	Gutierrez, Pablo Morentin: 1 article (07/2012)
8.	Heron, Nicola M: 1 article (07/2012)
9.	Heyes, Christine: 1 article (07/2012)
10.	Highton, Adrian J: 1 article (07/2012)

Related Diseases

1.	Osteoarthritis 07/26/2012 - "(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis."

Related Drugs and Biologics

1.	Cathepsin K
2.	indole