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6,6- dimethyl- 2- phenylethynyl- 7,8- dihydro- 6H- quinolin- 5- one

an antagonist of metabotropic glutamate receptor 5; structure in first source

Also Known As:

MRZ-8676

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one: 1

Experts

1.	Danysz, Wojciech: 1 article (12/2011)
2.	Dekundy, Andrzej: 1 article (12/2011)
3.	Gravius, Andreas: 1 article (12/2011)
4.	Hechenberger, Mirko: 1 article (12/2011)
5.	Mela, Flora: 1 article (12/2011)
6.	Nagel, Jens: 1 article (12/2011)
7.	Parsons, Christopher G: 1 article (12/2011)
8.	Pietraszek, Małgorzata: 1 article (12/2011)
9.	Tober, Carsten: 1 article (12/2011)
10.	van der Elst, Martine: 1 article (12/2011)

Related Diseases

1.	Pain (Aches) 12/01/2011 - "MRZ-8676 (25 mg/kg) was also effective in the formalin test, a rat model of persistent pain. "
2.	Dyskinesias (Dyskinesia) 12/01/2011 - "Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia."

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