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3- ((4- ((1,2,4)triazolo(1,5- a)pyridin- 6- yl)- 5- (6- methylpyridin- 2- yl)- 1H- imidazol- 2- yl)methylamino)benzonitrile

an ALK5 kinase inhibitor with antineoplastic activity; structure in first source

Also Known As:

EW 7195; EW-7195; EW7195

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - 3-((4-((1,2,4)triazolo(1,5-a)pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile: 1
  - Pyridines: 88
    - 3-((4-((1,2,4)triazolo(1,5-a)pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile: 1

Experts

1.	Jin, Cheng Hua: 1 article (11/2011)
2.	Kim, Dae-Kee: 1 article (11/2011)
3.	Nam, Jeong-Suk: 1 article (11/2011)
4.	Park, Chul-Yong: 1 article (11/2011)
5.	Sheen, Yhun Yhong: 1 article (11/2011)
6.	Son, Jee-Yeon: 1 article (11/2011)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 11/01/2011 - "Furthermore, in xenografted Balb/c and MMTV/cNeu mice, EW-7195 inhibited metastasis to lung from breast tumours. " 11/01/2011 - "The novel ALK5 inhibitor, EW-7195, efficiently inhibited TGF-β(1)-induced Smad signaling, EMT and breast tumour metastasis to the lung in vivo, demonstrating that EW-7195 has therapeutic potential for the breast cancer metastasis to the lung." 11/01/2011 - "In addition, the suppressive effects of EW-7195 on mammary cancer metastasis to lung were examined using a Balb/c xenograft and MMTV/cNeu transgenic mice model system. " 11/01/2011 - "EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung."
2.	Breast Neoplasms (Breast Cancer) 11/01/2011 - "The novel ALK5 inhibitor, EW-7195, efficiently inhibited TGF-β(1)-induced Smad signaling, EMT and breast tumour metastasis to the lung in vivo, demonstrating that EW-7195 has therapeutic potential for the breast cancer metastasis to the lung." 11/01/2011 - "In addition, the suppressive effects of EW-7195 on mammary cancer metastasis to lung were examined using a Balb/c xenograft and MMTV/cNeu transgenic mice model system. " 11/01/2011 - "EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung."

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