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BNS 22

has antineoplastic activity; structure in first source

Also Known As:

BNS-22; BNS22 cpd

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        BNS 22: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        BNS 22: 3
    - Quinolines: 146
      - BNS 22: 3

Experts

1.	Kimura, Shinya: 3 articles (10/2017 - 06/2011)
2.	Nagasaki, Yukio: 1 article (10/2017)
3.	Vong, Long Binh: 1 article (10/2017)
4.	Kawatani, Makoto: 1 article (06/2011)
5.	Maekawa, Taira: 1 article (06/2011)
6.	Muroi, Makoto: 1 article (06/2011)
7.	Osada, Hiroyuki: 1 article (06/2011)
8.	Takayama, Hiroshi: 1 article (06/2011)

Related Diseases

1.	Colitis-Associated Neoplasms 10/01/2017 - "As the result, BNS-22@siRNP significantly inhibits the tumor progression in colitis-associated colon cancer mice compared to other control treatments. " 10/01/2017 - "In this study, a newly designed silica-containing redox nanoparticle (siRNP) with reactive oxygen species (ROS) scavenging capacity is developed as an ideal oral nanocarrier for a novel hydrophobic anticancer compound BNS-22 to treat colitis-associated colon cancer in vivo. "
2.	Neoplasms (Cancer) 10/01/2017 - "As the result, BNS-22@siRNP significantly inhibits the tumor progression in colitis-associated colon cancer mice compared to other control treatments. " 07/01/2014 - "Furthermore, we synthesized BNS-22 as a derivative of GUT-70, which showed more antiproliferative activity against human cancer cells than GUT-70. " 06/24/2011 - "BNS-22, a chemically synthesized derivative of the natural plant product GUT-70, has antiproliferative activity against human cancer cells, the mechanism of which is unknown. " 10/01/2017 - "After oral administration to mice, BNS-22-loaded siRNP (BNS-22@siRNP) remarkably improves bioavailability and colonic tumor distribution of BNS-22. "
3.	Polyploidy 06/24/2011 - "Like ICRF-193, BNS-22 induces mitotic abnormalities, characterized by impairments in chromosome alignment and segregation, thereby causing polyploidy in HeLa cells. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Silicon Dioxide (Silica)
3.	BNS 22
4.	GUT-70
5.	4,4'- (1,2- dimethyl- 1,2- ethanediyl)bis- 2,6- piperazinedione

Related Therapies and Procedures

1.	Oral Administration