Coumarins

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid. The various coumarins have a wide range of proposed actions and uses including as ANTICOAGULANTS, pharmaceutical aids, indicators and reagents, photoreactive substances, and ANTINEOPLASTIC AGENTS.

Also Known As:

Networked: 240 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Supuran, Claudiu T: 9 articles (11/2015 - 08/2010)
2.	Iranshahi, Mehrdad: 7 articles (06/2015 - 02/2008)
3.	Maresca, Alfonso: 5 articles (04/2013 - 08/2010)
4.	Xiang, Ming: 4 articles (10/2015 - 11/2011)
5.	Scozzafava, Andrea: 4 articles (11/2014 - 12/2010)
6.	de Boer, Anthonius: 4 articles (08/2014 - 01/2008)
7.	Stricker, Bruno H Ch: 4 articles (01/2009 - 06/2002)
8.	Carta, Fabrizio: 3 articles (11/2015 - 04/2012)
9.	Winum, Jean-Yves: 3 articles (04/2013 - 12/2011)
10.	Klungel, Olaf H: 3 articles (01/2009 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "Therefore, we believe that it is necessaryto carry out further studies on the effect of coumarins compounds in anti-tumor. " 12/01/2015 - "This contains many active phytochemicals such as coumarins which possess anti-inflammatory and anti-cancer activities. " 01/01/2015 - "Natural coumarins have attraction due to their bioactive properties such as tumor promotion inhibitory effects, and anti-HIV activity. " 08/10/2014 - "This review examines the biological properties of coumarins, widely distributed at the highest levels in the fruit, followed by the roots, stems and leaves, by considering their beneficial effects in the prevention of some diseases and as anti-cancer agents. " 02/01/2014 - "Some of these 3,4-diphenyl coumarins, 7b-c (the double chains at 4-position on 3-,4-phenyl, respectively), and 13b-f (the double chains at 4-position on 3-phenyl and 7-position, respectively), showed a broad-spectrum and good anti-proliferative activity against five tumor cells and low cytotoxicity in osteoblast. "
2.	Hyperuricemia 09/01/2011 - "Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice." 09/01/2011 - "This study provides an evidence to support clinical therapeutic effects of cortex fraxini coumarines on hyperuricemia with renal dysfunction."
3.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2013 - "Dosing aids for coumarins with readily available clinical parameters may nevertheless be helpful for use in polymorbid hospitalised patients. " 07/01/2006 - "A lot of structurally different natural coumarins were found to display potent anti-HIV activity and continued progress is anticipated in the discovery of new leads and in the development of these agents as potential anti-AIDS drug candidates. " 07/01/2013 - "Coumarins are plant secondary metabolites that have demonstrated a variety of important therapeutic properties, such as antibacterial, anti-inflammatory, and anti-coagulant effects, as well as anti-cancer and anti-AIDS activities. " 06/01/2005 - "These results highlight the potential of the NF-kappaB transcription factor as a target for anti-HIV-1 compounds such as 4-phenyl coumarins, which could serve as lead compounds for the development of additional therapeutic approaches against AIDS." 10/01/1994 - "Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides."
4.	Body Weight (Weight, Body) 10/01/1983 - "A diet containing selenium in a concentration of 2.5 mg/kg of feed was protective against the toxic effects of both coumarins in pigs given 4 daily oral doses of 0.2 mg/kg of body weight. " 06/30/2006 - "This fraction containing steroids and coumarins showed anti-diabetes activity in alloxan diabetic rats as judged from serum glucose levels, liver glycogen content and body weight. " 10/01/2015 - "Total coumarins, at a dose of 50 or 100 mg/kg: 1) significantly increased body weight; 2) ameliorated morphological evidence of renal pathology; 3) decreased blood levels of glucose and urea nitrogen; 4) decreased albuminuria and serum creatinine; and 5) reduced protein and gene levels of transforming growth factor-β1, connective tissue growth factor, and toll-like receptor 4 in the kidneys. "
5.	Drug Toxicity (Drug Safety) 12/01/2010 - "In contrast, pharmacogenetic knowledge is frequently not yet translated into clinical practice, even though in some cases, particularly regarding drugs used in treatment of thrombotic diseases (e.g., coumarines, platelet aggregation inhibitors), it is already known that testing for genetic variants prior to pharmacotherapy may help to prevent severe adverse drug reactions or avoid therapeutic failure. " 09/01/2007 - "The use of new pharmacogenetics-based dosing schemes and the concomitant application of low-dose vitamin K with coumarins will decidedly influence the current practice of oral anticoagulation and greatly improve coumarin drug safety."

Related Drugs and Biologics

1.	coumarin
2.	psoralidin
3.	Cortex Fraxini
4.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)
5.	Vitamins
6.	Vitamin K 1 (Phylloquinone)
7.	esculetin
8.	Selenium
9.	Chalcones
10.	Flavonoids

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Angioplasty (Angioplasty, Transluminal)
3.	Chemoprevention
4.	Balloon Angioplasty
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)