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15-oxospiramilactone

an antineoplastic agent that inhibits canonical Wnt signaling; structure in first source

Also Known As:

NC043 compound

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - 15-oxospiramilactone: 2

Experts

1.	Bañuls, Celia: 1 article (01/2017)
2.	Diaz-Morales, Noelia: 1 article (01/2017)
3.	Hernandez-Mijares, Antonio: 1 article (01/2017)
4.	Rocha, Milagros: 1 article (01/2017)
5.	Rovira-Llopis, Susana: 1 article (01/2017)
6.	Victor, Victor M: 1 article (01/2017)
7.	Hao, Xiaojiang: 1 article (05/2011)
8.	Li, Lin: 1 article (05/2011)
9.	Liu, Haiyang: 1 article (05/2011)
10.	Wang, Sheng: 1 article (05/2011)

Related Diseases

1.	Carcinogenesis 05/01/2011 - "A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis."
2.	Type 2 Diabetes Mellitus (MODY) 01/01/2017 - "In this review, we discuss the molecular pathways of mitochondrial dynamics, their impairment under type 2 diabetes, and pharmaceutical approaches for targeting mitochondrial dynamics, such as mitochondrial division inhibitor-1 (mdivi-1), dynasore, P110 and 15-oxospiramilactone. "
3.	Colonic Neoplasms (Colon Cancer) 05/01/2011 - "The screen revealed a diterpenoid derivative, 15-oxospiramilactone (NC043) that inhibits Wnt3a or LiCl-stimulated Top-flash reporter activity in HEK293T cells and growth of colon cancer cells, SW480 and Caco-2. " 05/01/2011 - "A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis."

Related Drugs and Biologics

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2.	Diterpenes
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4.	N'- (3,4- dihydroxybenzylidene)- 3- hydroxy- 2- naphthahydrazide