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CAY10566

an SCD1 inhibitor; structure in first source

Also Known As:

2-(6-(4-(2-chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole; DFP2M-oxadiazole; cay-10566

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        CAY10566: 3
  - Pyridazines: 11
    - CAY10566: 3

Experts

1.	Forti, Fabio Luis: 1 article (09/2021)
2.	de Lima Luna, Arthur Cassio: 1 article (09/2021)
3.	Cai, C: 1 article (07/2016)
4.	Du, X: 1 article (07/2016)
5.	Shen, W: 1 article (07/2016)
6.	Yu, X Q: 1 article (07/2016)
7.	Baradaran, Behzad: 1 article (06/2014)
8.	Darabi, Maryam: 1 article (06/2014)
9.	Darabi, Masoud: 1 article (06/2014)
10.	Fayezi, Shabnam: 1 article (06/2014)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/20/2016 - "Inhibition of the expression of HIF-2α or SCD1 reduced the proliferation and invasion of HepG2 and SMMC-7721 cells and promoted apoptosis (P < 0.05); interference and downregulation of HIF-2α combined with inhibition of SCD1 expression by CAY10566 achieved significantly greater reductions in proliferation and invasion and a significantly greater increase in apoptosis rate of hepatoma cells, compared with inhibition of HIF-2α or SCD1 alone (P <0.05). "
2.	Neoplasms (Cancer) 09/01/2021 - "Therefore, HepG2 tumor cells were treated with the SCD1 inhibitor (CAY10566) to ensure a decrease in proliferation/survival, as confirmed by a lipidomic analysis that detected an efficient decrease in the concentration of MUFA. " 06/01/2014 - "While exhibiting no evident cytotoxicity, treatment with the SCD1 inhibitor, CAY10566 (0.1-1 µM), for 48 hours significantly increased 18:2n-6 levels in both the tumor and adjacent normal-appearing tissue (approximately 1.2 fold, p<0.05). "