trans- 3- (3,4- dimethoxyphenyl)- 4- ((E)- 3,4- dimethoxystyryl)cyclohex- 1- ene

structure in first source

Also Known As:

(+,-)-trans-3-(3,4-dimethoxyphenyl)-4-((E)-3,4-dimethoxystyryl)cyclohex-1-ene; NMac1; NMac1 compound; Nm23-H1 activator 1; PSC-1-ene cpd

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Styrenes: 6
        trans-3-(3,4-dimethoxyphenyl)-4-((E)-3,4-dimethoxystyryl)cyclohex-1-ene: 4
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        trans-3-(3,4-dimethoxyphenyl)-4-((E)-3,4-dimethoxystyryl)cyclohex-1-ene: 4

Experts

1.	Lee, Hee-Yoon: 2 articles (12/2021 - 07/2018)
2.	Lee, Jae-Jin: 2 articles (12/2021 - 07/2018)
3.	Lee, Kong-Joo: 2 articles (12/2021 - 07/2018)
4.	Suh, Ji-Wan: 2 articles (12/2021 - 07/2018)
5.	Hwang, Geum-Sook: 1 article (12/2021)
6.	Jung, Sunhee: 1 article (12/2021)
7.	Kim, Bokyung: 1 article (12/2021)
8.	Shin, Ji Soo: 1 article (12/2021)
9.	Choi, Jung-Eun: 1 article (07/2018)
10.	Kim, Eunice EunKyeong: 1 article (07/2018)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/19/2018 - "NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model. " 12/07/2021 - "In this study, we found that a small molecule phenylbutenoid dimer NMac1 (Nm23-H1 activator 1), (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, a previously identified anti-metastatic agent, has novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells. "
2.	Starvation 12/07/2021 - "NMac1 and NMac24 effectively suppress cancer cell proliferation in 3D-spheroid in vivo-like models only under glucose starvation. " 12/07/2021 - "NMac1 causes significant activation of AMPK by decreasing ATP synthesis, lowers mitochondrial membrane potential (MMP, ΔΨm), and inhibits oxygen consumption rate (OCR) under glucose starvation. " 12/07/2021 - "In this study, we found that a small molecule phenylbutenoid dimer NMac1 (Nm23-H1 activator 1), (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, a previously identified anti-metastatic agent, has novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells. "
3.	Neoplasms (Cancer) 11/01/2004 - "A new phenylbutenoid dimer, (+/-)- trans-3-(4-hydroxy-3-methoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (+/-)- trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3-diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. " 12/07/2021 - "These results suggest that NMac1 and NMac24 have the potential as anti-cancer agents having cytotoxic effects selectively in glucose restricted cells." 12/07/2021 - "NMac1 and NMac24 effectively suppress cancer cell proliferation in 3D-spheroid in vivo-like models only under glucose starvation. "
4.	Endometrial Neoplasms (Endometrial Cancer) 10/01/2001 - "Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer."
5.	Neoplasm Metastasis (Metastasis) 07/19/2018 - "NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model. "

Related Drugs and Biologics

1.	trans- 3- (3,4- dimethoxyphenyl)- 4- ((E)- 3,4- dimethoxystyryl)cyclohex- 1- ene
2.	Glucose (Dextrose)
3.	Matrix Metalloproteinases (MMPs)
4.	Adenosine Triphosphate (ATP)