HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

wiskostatin

induces folding of N-WASP's GTPase-binding domain into its autoinhibited conformation; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Guangxin: 1 article (01/2022)
2.	Cui, Jia: 1 article (01/2022)
3.	Li, Ping: 1 article (01/2022)
4.	Wen, Da: 1 article (01/2022)
5.	Wu, Changxin: 1 article (01/2022)
6.	Xiong, Qiuhong: 1 article (01/2022)
7.	Kajiyama, Hiroaki: 1 article (01/2020)
8.	Kikkawa, Fumitaka: 1 article (01/2020)
9.	Koya, Yoshihiro: 1 article (01/2020)
10.	Nawa, Akihiro: 1 article (01/2020)

Related Diseases

1.	Wiskott-Aldrich Syndrome 01/01/2019 - "Pharmacological pertubations of actin polymerization, a small molecule inhibitor of actin nucleation by the ARP2/3 complex - CK-548 - and the inhibitor of neural Wiskott-Aldrich syndrome proteins- Wiskostatin- inhibited JEV replication, highlighting the important role of the dynamic actin network. "
2.	Neoplasms (Cancer) 01/01/2020 - "Conversely, downregulation of cortactin or TKS5 or treatment with the MMP inhibitor GM6001 or the N-WASP inhibitor wiskostatin did not have any effect on cancer cell trans-mesothelial migration. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2017 - "These findings highlight nWASP as an important potential therapeutic target in lung cancer invasion and demonstrate that inhibiting nWASP activity using the inhibitor wiskostatin can significantly alter cell behaviour in vitro." 01/01/2017 - "Paxillin and FAK activity are reduced in lung cancer cell lines following wiskostatin and nWASP knockdown as shown by immunofluorescence and western blot. "
4.	Infections 01/01/2022 - "Analysis of the Cdc42, N-WASP, and Arp2/3 signaling pathways during Mtb infection revealed that knockdown of Cdc42 and N-WASP or the addition of ZCL278, Wiskostatin or CK636 (blockers of Cdc42, N-WASP, and Arp2/3, respectively) significantly exacerbated Mtb infection in lung epithelial cells. "
5.	Carcinoma (Carcinomatosis) 01/01/2017 - "The effect of wiskostatin, an nWASP inhibitor, on A-549 and SK-MES-1 lung carcinoma cell growth, adhesion, migration and invasion was also examined using several in vitro functional assays, including ECIS, and immunofluorescence staining. "

Related Drugs and Biologics

1.	Matrix Metalloproteinase Inhibitors
2.	Paxillin
3.	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)
4.	Cortactin
5.	Proteins (Proteins, Gene)
6.	CK-0993548
7.	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamide
8.	ZCL278