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vecabrutinib

Bruton tyrosine kinase (BTK) inhibitor

Also Known As:

(3R,4S)-1-(6-amino-5-fluoropyrimidin-4-yl)-3-((3R)-3-(3-chloro-5-(trifluoromethyl)anilino)-2-oxopiperidin-1-yl)piperidine-4-carboxamide

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - vecabrutinib: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - vecabrutinib: 5

Experts

1.	Fox, Judith A: 3 articles (10/2022 - 01/2022)
2.	Taverna, Pietro: 3 articles (10/2022 - 01/2022)
3.	Wierda, William G: 2 articles (01/2022 - 01/2022)
4.	Debatin, Klaus-Michael: 1 article (10/2022)
5.	Dheenadayalan, Rashmi Priyadharshini: 1 article (10/2022)
6.	Endres, Sascha: 1 article (10/2022)
7.	Gierschik, Peter: 1 article (10/2022)
8.	Jebaraj, Billy Michael Chelliah: 1 article (10/2022)
9.	Mertens, Daniel: 1 article (10/2022)
10.	Meyer, Lüder Hinrich: 1 article (10/2022)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2022 - "In the murine Eμ-TCL1 adoptive transfer model, vecabrutinib reduced tumor burden and significantly improved survival. " 01/01/2022 - "Phase Ib dose-escalation study of the selective, non-covalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies."
2.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 10/01/2022 - "Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia." 01/01/2022 - "Vecabrutinib inhibits B-cell receptor signal transduction in chronic lymphocytic leukemia cell types with wild-type or mutant Bruton tyrosine kinase."
3.	Lymphoma (Lymphomas) 09/20/2023 - "Finally, the relapsed lymphoma cells showed in vitro resistance to standard BTK inhibitors but sensitivity to vecabrutinib, active against mutated BTK, and to PIM1 inhibitor. "
4.	Atrial Fibrillation 01/01/2023 - "acalabrutinib, zanubrutinib, and vecabrutinib) were tested and their lower toxicity (atrial fibrillation) was documented. "

Related Drugs and Biologics

1.	Agammaglobulinaemia Tyrosine Kinase
2.	zanubrutinib
3.	acalabrutinib