JNJ-54175446

a brain permeable P2X7 antagonist

Also Known As:

(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoro-2-pyrimidinyl)-4-methyl-1,4,6,7-tetrahydro-5H-(1,2,3)triazolo(4,5-c)pyridin-5-yl)methanone; Methanone, (2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoro-2-pyrimidinyl)-1,4,6,7-tetrahydro-4-methyl-5H-1,2,3-triazolo(4,5-c)pyridin-5-yl)-

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Azoles: 2199
    - Triazoles: 1573
      - JNJ-54175446: 2
  - Pyridines: 91
    - JNJ-54175446: 2

Experts

1.	Ceusters, Marc: 2 articles (01/2023 - 01/2023)
2.	Benes, Heike: 1 article (01/2023)
3.	Bhatacharya, Anindya: 1 article (01/2023)
4.	Bhattacharya, Anindya: 1 article (01/2023)
5.	Browning, Michael: 1 article (01/2023)
6.	Drevets, Wayne C: 1 article (01/2023)
7.	Engel, Tobias: 1 article (01/2023)
8.	Heiland, Mona: 1 article (01/2023)
9.	Heller, Janosch P: 1 article (01/2023)
10.	Henshall, David C: 1 article (01/2023)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/2023 - "In contrast, once-daily dosing of JNJ-54175446 (30 mg/kg, intraperitoneal) resulted in a significant reduction in spontaneous recurrent seizures which lasted several days after the end of drug administration. "
2.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2023 - "This was a double-blind, placebo-controlled, randomized study to assess the safety and pharmacokinetics of JNJ-54175446 and explore its effects in patients with single episode and recurrent major depressive disorder (MDD) (N = 69) and baseline total Inventory of Depressive Symptomatology Clinician Rated (IDS-C) > 30. " 01/01/2023 - "Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder."
3.	Anhedonia 01/01/2023 - "However, JNJ-54175446 blunted an acute reduction of anhedonia that occurred as a result of TSD, assessed by the Snaith-Hamilton Pleasure Scale (SHAPS) and the Probabilistic Instrumental Learning Task (PILT)."
4.	Temporal Lobe Epilepsy 01/01/2023 - "Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice."

Related Drugs and Biologics

1.	Purinergic P2X7 Receptors
2.	Kainic Acid (Kainate)
3.	purine