KYA1797K

small molecule that degrades both beta-catenin and Ras via GSK3beta activation

Also Known As:

(5Z)-5-((5-(4-Nitrophenyl)-2-furanyl)methylene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt; (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid potassium salt

Networked: 14 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidines: 105
      - KYA1797K: 14

Experts

1.	Choi, Kang-Yell: 8 articles (01/2021 - 01/2016)
2.	Cho, Yong-Hee: 6 articles (01/2020 - 01/2016)
3.	Han, Gyoonhee: 4 articles (01/2021 - 01/2016)
4.	Cha, Pu-Hyeon: 4 articles (01/2020 - 01/2016)
5.	Lee, Sang-Kyu: 4 articles (04/2019 - 01/2016)
6.	Min, Do Sik: 4 articles (04/2019 - 01/2016)
7.	Ryu, Won-Ji: 3 articles (01/2021 - 04/2019)
8.	Ro, Eun Ji: 3 articles (01/2020 - 01/2018)
9.	Jeong, Woo-Jeong: 3 articles (11/2018 - 01/2016)
10.	Cho, Jaebeom: 2 articles (01/2020 - 01/2019)

Related Diseases

1.	Infections 01/01/2021 - "iCRT14 and KYA1797K significantly inhibited HSV-1 productive infection in human and mouse neuronal cells and monkey kidney cells (VERO). " 01/01/2021 - "Although iCRT14 was only effective when present throughout infection, delayed addition or early removal of KYA1797K did not significantly reduce its antiviral properties. "
2.	Neoplasms (Cancer) 01/01/2020 - "Moreover, KYA1797K also suppresses the stemness of cells in CRC patient avatar model systems, such as patient-derived tumor organoids (PDTOs) and patient-derived tumor xenograft (PDTX). " 04/08/2019 - "The efficacy test of the drugs using gastric tumor organoids of Apc1638N mice showed that the CD44 and ALDH1A3 cancer stem cell markers were induced by FOLFOX, but not by KYA1797K. " 11/20/2018 - "KYA1797K suppressed the growth of tumor xenografts induced by CRC cells as well as tumor organoids derived from CRC patients having both APC and KRAS mutations. " 01/01/2020 - "KYA1797K also suppressed the stemness of 3D-cultured PDCs and xenografted tumors established by using residual tumors from TNBC patients and those established by the TNBC cell line. " 01/01/2016 - "KYA1797K effectively suppressed the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo studies using xenograft and transgenic mouse models of tumors induced by APC and KRAS mutations. "
3.	Colorectal Neoplasms (Colorectal Cancer) 04/08/2019 - "On the basis of our previous studies, where small molecules to suppress colorectal cancer (CRC) via degrading both β-catenin and RAS were developed, we tested the effectiveness of KYA1797K, a representative compound functioning by binding axin, in the growth of GC cells. " 01/01/2020 - "KYA1797K, a β-catenin inhibitor, has been identified for its functionality as a tumor suppressor gene in colorectal cancer through inhibition of the Wnt/β-catenin signaling pathway. " 01/01/2019 - "This study aims to show the effectiveness of KYA1797K, a small molecule which revealed anti-cancer effect in colorectal cancer by destabilizing Ras via inhibiting the Wnt/β-catenin pathway, for the treatment of KRAS-mutated NSCLC. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 11/01/2022 - "In cultured proximal tubular cells, KYA1797K shows a better effect on inhibiting cellular senescence and could better suppress mitochondrial dysfunction and ameliorate the fibrotic changes, at the same dose as that in ICG-001. " 10/01/2023 - "Furthermore, KYA1797K, a destabilizer of β-catenin, greatly inhibited PTX3-induced mitochondrial dysfunction, tubular cell senescence, and renal fibrosis. "
5.	Fibrosis (Cirrhosis) 11/01/2022 - "In D-gal-treated accelerated aging mice, KYA1797K could greatly inhibit β-catenin pathway, preserve mitochondrial homeostasis, repress cellular senescence, and retard age-related kidney fibrosis. " 10/01/2023 - "Furthermore, KYA1797K, a destabilizer of β-catenin, greatly inhibited PTX3-induced mitochondrial dysfunction, tubular cell senescence, and renal fibrosis. "

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	iCRT14
3.	Catenins
4.	Calcibiotic Root Canal Sealer
5.	GTP-Binding Proteins (G-Protein)
6.	Paclitaxel (Taxol)
7.	Tyrosine Kinase Inhibitors
8.	ICG 001

Related Therapies and Procedures

1.	Immunotherapy