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N,N'- bis- (2,4- dimethyl- phenyl)- ethane- 1,2- diamine

functions as an inhibitor of transcription factor NF-kappaB and potentiates the antitumor effect of bortezomib in multiple myeloma

Also Known As:

DANFIN

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - N,N'-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine: 1

Experts

1.	Hayashi, Minoru: 1 article (01/2018)
2.	Imai, Yuuki: 1 article (01/2018)
3.	Kido, Kohki: 1 article (01/2018)
4.	Manabe, Erika: 1 article (01/2018)
5.	Sawasaki, Tatsuya: 1 article (01/2018)
6.	Takahashi, Hirotaka: 1 article (01/2018)
7.	Takeda, Hiroyuki: 1 article (01/2018)
8.	Uematsu, Atsushi: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "The combination therapy of DANFIN with bortezomib dramatically enhanced the apoptosis of multiple myeloma cells and indicated a remarkable anti-tumor effect in a multiple-myeloma xenograft mouse model."
2.	Multiple Myeloma 01/01/2018 - "Furthermore, in multiple myeloma cells, DANFIN suppressed the expression level of NF-κB target genes and induced apoptosis. " 01/01/2018 - "We demonstrate here that DANFIN (N,N'-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine) functions as an inhibitor of the p65 family proteins and induces chemosensitization to bortezomib in multiple myeloma. " 01/01/2018 - "DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma." 01/01/2018 - "The combination therapy of DANFIN with bortezomib dramatically enhanced the apoptosis of multiple myeloma cells and indicated a remarkable anti-tumor effect in a multiple-myeloma xenograft mouse model."

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Proteins (Proteins, Gene)
3.	Bortezomib (Velcade)

Related Therapies and Procedures

1.	Therapeutics