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CC-885

a cereblon modulator with antineoplastic activity; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Yulu: 2 articles (01/2021 - 09/2020)
2.	Hu, Min: 2 articles (01/2021 - 09/2020)
3.	Liu, Bin: 2 articles (01/2021 - 09/2020)
4.	Balgi, Aruna D: 1 article (01/2021)
5.	Baradaran-Heravi, Alireza: 1 article (01/2021)
6.	Chen, Yong: 1 article (01/2021)
7.	Choi, Kunho: 1 article (01/2021)
8.	Fang, Baijun: 1 article (01/2021)
9.	Has, Cristina: 1 article (01/2021)
10.	Hosseini-Farahabadi, Sara: 1 article (01/2021)

Related Diseases

1.	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/01/2021 - "CC-90009 is considerably less toxic than CC-885 and it enhances PTC readthrough in combination with aminoglycosides in mucopolysaccharidosis type I-Hurler, late infantile neuronal ceroid lipofuscinosis, Duchenne muscular dystrophy and junctional epidermolysis bullosa patient-derived cells with nonsense mutations in the IDUA, TPP1, DMD and COL17A1 genes, respectively. "
2.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 01/01/2021 - "CC-90009 is considerably less toxic than CC-885 and it enhances PTC readthrough in combination with aminoglycosides in mucopolysaccharidosis type I-Hurler, late infantile neuronal ceroid lipofuscinosis, Duchenne muscular dystrophy and junctional epidermolysis bullosa patient-derived cells with nonsense mutations in the IDUA, TPP1, DMD and COL17A1 genes, respectively. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2017 - "Another new cereblon modulator CC-885 is shown to induce degradation of the translation termination factor GSPT1, resulting in an antiproliferative effect in acute myeloid leukemia. "
4.	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/01/2021 - "CC-90009 is considerably less toxic than CC-885 and it enhances PTC readthrough in combination with aminoglycosides in mucopolysaccharidosis type I-Hurler, late infantile neuronal ceroid lipofuscinosis, Duchenne muscular dystrophy and junctional epidermolysis bullosa patient-derived cells with nonsense mutations in the IDUA, TPP1, DMD and COL17A1 genes, respectively. "
5.	Multiple Myeloma 01/01/2021 - "Although the degradation of GSPT1 is essential for the broad in vitro antitumor activity of CC-885, it is unclear whether other neosubstrates also contribute to the pharmacological effects of CC-885, especially in multiple myeloma (MM). " 01/01/2021 - "Cereblon modulator CC-885 induces CRBN-dependent ubiquitination and degradation of CDK4 in multiple myeloma."

Related Drugs and Biologics

1.	Nonsense Codon (Nonsense Mutation)
2.	Aminoglycosides
3.	BI 6727
4.	CC-90009