Kevin Sinchak Selected Research

Lordosis

1/2019	Plasma membrane G protein-coupled estrogen receptor 1 (GPER) mediates rapid estradiol facilitation of sexual receptivity through the orphanin-FQ-ORL-1 system in estradiol primed female rats.
1/2017	Tamoxifen and ICI 182,780 activate hypothalamic G protein-coupled estrogen receptor 1 to rapidly facilitate lordosis in female rats.
1/2016	Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
1/2015	Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female.
9/2014	17β-estradiol rapidly facilitates lordosis through G protein-coupled estrogen receptor 1 (GPER) via deactivation of medial preoptic nucleus μ-opioid receptors in estradiol primed female rats.
1/2014	Estradiol upregulates progesterone receptor and orphanin FQ colocalization in arcuate nucleus neurons and opioid receptor-like receptor-1 expression in proopiomelanocortin neurons that project to the medial preoptic nucleus in the female rat.
9/2013	Estradiol dose-dependent regulation of membrane estrogen receptor-α, metabotropic glutamate receptor-1a, and their complexes in the arcuate nucleus of the hypothalamus in female rats.
6/2013	Modulation of the arcuate nucleus-medial preoptic nucleus lordosis regulating circuit: a role for GABAB receptors.
11/2011	Orphanin FQ in the mediobasal hypothalamus facilitates sexual receptivity through the deactivation of medial preoptic nucleus mu-opioid receptors.
3/2007	Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis.

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Kevin Sinchak Research Topics

Disease

14	Lordosis 01/2019 - 03/2003
1	Intellectual Disability (Idiocy) 06/2008
1	Epilepsy (Aura) 06/2008
1	Hyperalgesia 08/2006

Drug/Important Bio-Agent (IBA)

9	Estradiol (Delestrogen)FDA LinkGeneric 01/2019 - 03/2007
8	Opioid Receptors (Opioid Receptor)IBA 01/2019 - 12/2004
5	NociceptinIBA 01/2019 - 05/2006
5	EndorphinsIBA 01/2019 - 11/2011
4	SteroidsIBA 01/2015 - 10/2005
4	Progesterone FDA LinkGeneric 01/2014 - 10/2005
3	GTP-Binding Proteins (G-Protein)IBA 01/2019 - 09/2014
3	Estrogen Receptor alphaIBA 01/2019 - 09/2014
3	estradiol 3-benzoate (estradiol benzoate)IBA 09/2014 - 06/2013
3	Estrogens (Estrogen)FDA Link 05/2006 - 03/2003
2	(Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)IBA 01/2019 - 11/2011
2	Benzoates (Benzoate)IBA 01/2019 - 12/2004
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2016 - 11/2011
2	LigandsIBA 11/2011 - 12/2004
2	Morphine (MS Contin)FDA LinkGeneric 08/2006 - 03/2003
2	mu Opioid Receptors (mu Opioid Receptor)IBA 10/2005 - 03/2003
1	Biotin (Vitamin H)FDA Link 01/2019
1	Fulvestrant (Faslodex)FDA Link 01/2017
1	Tamoxifen FDA LinkGeneric 01/2017
1	Estrogen ReceptorsIBA 01/2017
1	Hormones (Hormone)IBA 01/2015
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2011
1	NeurosteroidsIBA 06/2008
1	Dizocilpine Maleate (Dizocilpine)IBA 08/2006
1	delta Opioid Receptors (delta Opioid Receptor)IBA 12/2004
1	EnkephalinsIBA 12/2004
1	D-Penicillamine (2,5)- EnkephalinIBA 12/2004

Therapy/Procedure

1	Cannula 12/2004
1	Intraventricular Infusions 12/2004