Keith T Flaherty Selected Research

DNA (Deoxyribonucleic Acid)

3/2024	Phase 1/2 study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors.
1/2022	STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.
1/2022	Spartalizumab or placebo in combination with dabrafenib and trametinib in patients with BRAF V600-mutant melanoma: exploratory biomarker analyses from a randomized phase 3 trial (COMBI-i).
1/2022	Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.
1/2021	Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study.
10/2020	The Molecular Analysis for Therapy Choice (NCI-MATCH) Trial: Lessons for Genomic Trial Design.
1/2012	Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Keith T Flaherty Research Topics

Disease

221	Melanoma (Melanoma, Malignant) 06/2024 - 03/2004
173	Neoplasms (Cancer) 04/2024 - 04/2003
25	Disease Progression 04/2024 - 08/2009
24	Neoplasm Metastasis (Metastasis) 01/2022 - 12/2009
23	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 11/2005
10	Breast Neoplasms (Breast Cancer) 01/2023 - 03/2006
7	Brain Neoplasms (Brain Tumor) 01/2021 - 12/2009
7	Hypertension (High Blood Pressure) 10/2018 - 11/2005
7	Neutropenia 03/2014 - 04/2003
6	Adenocarcinoma 03/2024 - 01/2017
6	Fatigue 01/2022 - 04/2004
6	Exanthema (Rash) 01/2022 - 06/2006
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 04/2010
5	Thrombocytopenia (Thrombopenia) 02/2005 - 04/2003
4	Lymphoma (Lymphomas) 04/2024 - 01/2020
4	Inflammation (Inflammations) 01/2022 - 07/2014
4	Nausea 01/2022 - 04/2004
4	Nevus (Nevi) 06/2021 - 06/2006
4	Fever (Fevers) 01/2021 - 11/2012
4	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 04/2010
4	Keratoacanthoma 03/2014 - 06/2011
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2014 - 06/2011
3	Sarcoma (Soft Tissue Sarcoma) 06/2024 - 11/2010
3	Residual Neoplasm 12/2023 - 01/2018
3	Vomiting 01/2022 - 04/2004
3	Diarrhea 01/2022 - 06/2011
3	Kidney Neoplasms (Kidney Cancer) 01/2020 - 01/2007
3	Colonic Neoplasms (Colon Cancer) 01/2020 - 07/2015
3	Uveal melanoma 12/2018 - 10/2013
3	Arthralgia (Joint Pain) 10/2018 - 06/2011
3	Glioblastoma (Glioblastoma Multiforme) 09/2016 - 04/2010
2	Carcinoma (Carcinomatosis) 04/2024 - 01/2013
2	Skin Neoplasms (Skin Cancer) 05/2023 - 01/2020

Drug/Important Bio-Agent (IBA)

58	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 04/2024 - 05/2006
38	VemurafenibIBA 04/2024 - 08/2010
33	Sorafenib (BAY 43-9006)FDA Link 01/2020 - 03/2006
28	trametinibIBA 05/2024 - 07/2012
25	Immune Checkpoint InhibitorsIBA 02/2024 - 03/2013
25	Biomarkers (Surrogate Marker)IBA 01/2023 - 03/2010
24	dabrafenibIBA 05/2024 - 01/2011
19	Phosphotransferases (Kinase)IBA 01/2023 - 03/2008
15	Mitogen-Activated Protein KinasesIBA 01/2022 - 05/2006
13	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2014
12	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 06/2024 - 12/2009
12	binimetinibIBA 04/2024 - 08/2016
10	encorafenibIBA 04/2024 - 01/2018
10	Proteins (Proteins, Gene)FDA Link 10/2020 - 06/2006
10	IpilimumabIBA 01/2018 - 01/2012
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2016 - 03/2006
9	AntigensIBA 02/2024 - 07/2010
9	Carboplatin (JM8)FDA LinkGeneric 01/2016 - 09/2003
9	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2016 - 08/2009
8	CytokinesIBA 11/2023 - 07/2009
8	Paclitaxel (Taxol)FDA LinkGeneric 01/2016 - 09/2003
7	DNA (Deoxyribonucleic Acid)IBA 03/2024 - 01/2012
7	Dacarbazine (DIC)FDA LinkGeneric 01/2020 - 06/2011
7	Sunitinib (Sutent)FDA Link 01/2020 - 07/2007
6	LigandsIBA 01/2018 - 06/2006
5	AntibodiesIBA 11/2023 - 06/2006
5	cobimetinibIBA 01/2021 - 01/2018
5	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 11/2019 - 01/2007
5	Transcription Factors (Transcription Factor)IBA 01/2019 - 01/2013
5	raf KinasesIBA 08/2017 - 03/2006
5	Imatinib Mesylate (Gleevec)FDA Link 08/2015 - 07/2008
4	InterferonsIBA 01/2022 - 03/2009
4	Interleukin-2 (IL2)IBA 06/2021 - 06/2014
4	Gemcitabine FDA Link 01/2020 - 09/2003
4	Monoclonal AntibodiesIBA 11/2019 - 03/2007
4	Microphthalmia-Associated Transcription FactorIBA 01/2019 - 10/2014
4	Proto-Oncogene Proteins B-rafIBA 01/2019 - 09/2010
4	PLX 4720IBA 08/2017 - 01/2012
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2015 - 05/2006
4	Bevacizumab (Avastin)FDA Link 08/2015 - 05/2008
4	Angiogenesis InhibitorsIBA 01/2013 - 04/2008
3	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 04/2024 - 01/2020
3	EnzymesIBA 02/2024 - 12/2015
3	Retinoblastoma ProteinIBA 01/2023 - 01/2012
3	palbociclibIBA 01/2023 - 01/2012
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 12/2012
3	B7-H1 AntigenIBA 01/2022 - 09/2017
3	spartalizumabIBA 01/2022 - 10/2020
3	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 06/2009
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2020 - 01/2016
3	TensinsIBA 10/2020 - 01/2016
3	NivolumabIBA 01/2020 - 10/2013
3	Differentiation AntigensIBA 01/2020 - 01/2013
3	Drug CombinationsIBA 01/2019 - 08/2017
3	pembrolizumabIBA 01/2018 - 10/2013
3	Small Interfering RNA (siRNA)IBA 09/2016 - 01/2013
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2016 - 01/2013
3	Tyrosine (L-Tyrosine)FDA Link 03/2012 - 10/2008
3	Cyclin-Dependent Kinase 4IBA 01/2012 - 07/2008
3	Cisplatin (Platino)FDA LinkGeneric 06/2009 - 04/2003
2	erdafitinibIBA 04/2024 - 04/2024
2	Trastuzumab (Herceptin)FDA Link 03/2024 - 03/2006
2	NAD (NADH)IBA 02/2024 - 09/2016

Therapy/Procedure

165	Therapeutics 06/2024 - 03/2004
40	Immunotherapy 04/2024 - 04/2006
16	Drug Therapy (Chemotherapy) 11/2019 - 04/2006
6	Precision Medicine 06/2023 - 02/2014