Keith T Flaherty Selected Research

Antigens

2/2024	Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.
1/2022	STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.
6/2021	Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells.
1/2021	Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses.
1/2016	Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
10/2013	BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes.
6/2013	Ipilimumab for patients with advanced mucosal melanoma.
3/2013	BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.
7/2010	Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.

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Keith T Flaherty Research Topics

Disease

221	Melanoma (Melanoma, Malignant) 06/2024 - 03/2004
173	Neoplasms (Cancer) 04/2024 - 04/2003
25	Disease Progression 04/2024 - 08/2009
24	Neoplasm Metastasis (Metastasis) 01/2022 - 12/2009
23	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 11/2005
10	Breast Neoplasms (Breast Cancer) 01/2023 - 03/2006
7	Brain Neoplasms (Brain Tumor) 01/2021 - 12/2009
7	Hypertension (High Blood Pressure) 10/2018 - 11/2005
7	Neutropenia 03/2014 - 04/2003
6	Adenocarcinoma 03/2024 - 01/2017
6	Fatigue 01/2022 - 04/2004
6	Exanthema (Rash) 01/2022 - 06/2006
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 04/2010
5	Thrombocytopenia (Thrombopenia) 02/2005 - 04/2003
4	Lymphoma (Lymphomas) 04/2024 - 01/2020
4	Inflammation (Inflammations) 01/2022 - 07/2014
4	Nausea 01/2022 - 04/2004
4	Nevus (Nevi) 06/2021 - 06/2006
4	Fever (Fevers) 01/2021 - 11/2012
4	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 04/2010
4	Keratoacanthoma 03/2014 - 06/2011
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2014 - 06/2011
3	Sarcoma (Soft Tissue Sarcoma) 06/2024 - 11/2010
3	Residual Neoplasm 12/2023 - 01/2018
3	Vomiting 01/2022 - 04/2004
3	Diarrhea 01/2022 - 06/2011
3	Kidney Neoplasms (Kidney Cancer) 01/2020 - 01/2007
3	Colonic Neoplasms (Colon Cancer) 01/2020 - 07/2015
3	Uveal melanoma 12/2018 - 10/2013
3	Arthralgia (Joint Pain) 10/2018 - 06/2011
3	Glioblastoma (Glioblastoma Multiforme) 09/2016 - 04/2010
2	Carcinoma (Carcinomatosis) 04/2024 - 01/2013
2	Skin Neoplasms (Skin Cancer) 05/2023 - 01/2020

Drug/Important Bio-Agent (IBA)

58	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 04/2024 - 05/2006
38	VemurafenibIBA 04/2024 - 08/2010
33	Sorafenib (BAY 43-9006)FDA Link 01/2020 - 03/2006
28	trametinibIBA 05/2024 - 07/2012
25	Immune Checkpoint InhibitorsIBA 02/2024 - 03/2013
25	Biomarkers (Surrogate Marker)IBA 01/2023 - 03/2010
24	dabrafenibIBA 05/2024 - 01/2011
19	Phosphotransferases (Kinase)IBA 01/2023 - 03/2008
15	Mitogen-Activated Protein KinasesIBA 01/2022 - 05/2006
13	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2014
12	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 06/2024 - 12/2009
12	binimetinibIBA 04/2024 - 08/2016
10	encorafenibIBA 04/2024 - 01/2018
10	Proteins (Proteins, Gene)FDA Link 10/2020 - 06/2006
10	IpilimumabIBA 01/2018 - 01/2012
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2016 - 03/2006
9	AntigensIBA 02/2024 - 07/2010
9	Carboplatin (JM8)FDA LinkGeneric 01/2016 - 09/2003
9	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2016 - 08/2009
8	CytokinesIBA 11/2023 - 07/2009
8	Paclitaxel (Taxol)FDA LinkGeneric 01/2016 - 09/2003
7	DNA (Deoxyribonucleic Acid)IBA 03/2024 - 01/2012
7	Dacarbazine (DIC)FDA LinkGeneric 01/2020 - 06/2011
7	Sunitinib (Sutent)FDA Link 01/2020 - 07/2007
6	LigandsIBA 01/2018 - 06/2006
5	AntibodiesIBA 11/2023 - 06/2006
5	cobimetinibIBA 01/2021 - 01/2018
5	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 11/2019 - 01/2007
5	Transcription Factors (Transcription Factor)IBA 01/2019 - 01/2013
5	raf KinasesIBA 08/2017 - 03/2006
5	Imatinib Mesylate (Gleevec)FDA Link 08/2015 - 07/2008
4	InterferonsIBA 01/2022 - 03/2009
4	Interleukin-2 (IL2)IBA 06/2021 - 06/2014
4	Gemcitabine FDA Link 01/2020 - 09/2003
4	Monoclonal AntibodiesIBA 11/2019 - 03/2007
4	Microphthalmia-Associated Transcription FactorIBA 01/2019 - 10/2014
4	Proto-Oncogene Proteins B-rafIBA 01/2019 - 09/2010
4	PLX 4720IBA 08/2017 - 01/2012
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2015 - 05/2006
4	Bevacizumab (Avastin)FDA Link 08/2015 - 05/2008
4	Angiogenesis InhibitorsIBA 01/2013 - 04/2008
3	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 04/2024 - 01/2020
3	EnzymesIBA 02/2024 - 12/2015
3	Retinoblastoma ProteinIBA 01/2023 - 01/2012
3	palbociclibIBA 01/2023 - 01/2012
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 12/2012
3	B7-H1 AntigenIBA 01/2022 - 09/2017
3	spartalizumabIBA 01/2022 - 10/2020
3	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 06/2009
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2020 - 01/2016
3	TensinsIBA 10/2020 - 01/2016
3	NivolumabIBA 01/2020 - 10/2013
3	Differentiation AntigensIBA 01/2020 - 01/2013
3	Drug CombinationsIBA 01/2019 - 08/2017
3	pembrolizumabIBA 01/2018 - 10/2013
3	Small Interfering RNA (siRNA)IBA 09/2016 - 01/2013
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2016 - 01/2013
3	Tyrosine (L-Tyrosine)FDA Link 03/2012 - 10/2008
3	Cyclin-Dependent Kinase 4IBA 01/2012 - 07/2008
3	Cisplatin (Platino)FDA LinkGeneric 06/2009 - 04/2003
2	erdafitinibIBA 04/2024 - 04/2024
2	Trastuzumab (Herceptin)FDA Link 03/2024 - 03/2006
2	NAD (NADH)IBA 02/2024 - 09/2016

Therapy/Procedure

165	Therapeutics 06/2024 - 03/2004
40	Immunotherapy 04/2024 - 04/2006
16	Drug Therapy (Chemotherapy) 11/2019 - 04/2006
6	Precision Medicine 06/2023 - 02/2014