Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced by D,L-allylglycine.

Abstract

The antagonism of various seizure and time-related components of the convulsions resulting after IV injection of D,L-allylglycine into male Wistar rats were assessed in a standard test procedure. Trimethadione and ethosuximide did not antagonize the seizure components, whereas clonazepam, phenobarbital, diphenylhydantoin, primidone, valproate sodium, aminoxyacetic acid, etomidate, acetazolamide, flunarizine, pipamperone and baclofen did. The allylglycine test may thus represent a relatively specific method of differentiating between drugs effective against partial or generalized convulsive seizures from those effective against absence seizures. The neuroleptics haloperidol and pimozide were completely inactive in contrast to their reported antagonism of bicuculine seizures. The spectra of the active substances are discussed with respect to Principal Component and Cluster Analysis. Noteworthy are the similarities between baclofen and etomidate; between aminoxyacetic acid, phenobarbital and valproate sodium; and between diphenylhydantoin and flunarizine.

• Authors: D Ashton, A Wauquier
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 11 Issue 2 Pg. 221-6 (Aug 1979) ISSN: 0091-3057 [Print] United States
• PMID: 41264 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Antipsychotic Agents
• Allylglycine
• gamma-Aminobutyric Acid
• Glycine

Topics

• Allylglycine (antagonists & inhibitors, pharmacology)
• Animals
• Anticonvulsants (pharmacology)
• Antipsychotic Agents (pharmacology)
• Glycine (analogs & derivatives)
• Male
• Rats
• Seizures (chemically induced, prevention & control)
• gamma-Aminobutyric Acid (physiology)