Primidone (Sertan)

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333 relevant articles (29 outcomes, 28 trials/studies) found for this Drug

Description: An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)

Also Known As:

Sertan; Mysoline; Apo-Primidone; Liskantin; Mylepsinum; Resimatil; Apotex Brand of Primidone; Astra Brand of Primidone; AstraZeneca Brand of Primidone; Desitin Brand of Primidone; Draxis Brand of Primidone; Holsten Brand of Primidone; Misodine; Mizodin; Primidon Holsten; Sanofi-Synthelabo Brand of Primidone; Xcel Brand of Primidone; Zeneca Brand of Primidone; Desoxyphenobarbital; Primaclone; 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Experts

1.	Payen, Christine: 1 article (07/2006)
2.	Descotes, Jacques: 1 article (07/2006)
3.	Witsenhausen, Jean-Paul: 1 article (07/2006)
4.	Pulce, Corine: 1 article (07/2006)
5.	Sosa, A L: 1 article (05/2005)
6.	Espinola, M: 1 article (05/2005)
7.	Ruiz, I: 1 article (05/2005)
8.	Ramirez-Bermudez, J: 1 article (05/2005)
9.	Campillo, C: 1 article (05/2005)
10.	Lopez-Gomez, M: 1 article (05/2005)

Related Diseases

1.	Seizures (Seizure) 09/01/1988 - "Efficacy of primidone for seizure control in neonates and young infants." 05/01/2005 - "Depression was common and associated with inadequate seizure control and use of primidone." 05/01/2005 - "After logistic regression, inadequate seizure control (OR 3.08, 95% CI 1.40-6.77, P=0.005) and use of primidone (OR 4.08, 95% CI 2.09-7.98; P<0.001) remained significantly associated" 11/22/2003 - "If primidone treatment is discontinued too quickly, withdrawal seizures may appear, some of which may be severe" 10/01/2000 - "The primidone dose was then increased by 125 to 250 mg every 3 weeks until adverse events or a seizure-free state was reached" Get all the results and reference details, order at left...
2.	Essential Tremor (Essential Tremors) 01/17/1981 - "Primidone is highly effective in benign familial tremor" 09/01/1985 - "Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice" 02/01/1990 - "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions" 01/01/1986 - "Primidone is an effective agent for the treatment of essential tremor." 01/01/1986 - "Efficacy of primidone in essential tremor." Get all the results and reference details, order at left...
3.	Tremor (Tremors) 01/01/1991 - "The tremor had not been helped by beta-blockers or primidone" 05/21/2007 - "Medical treatment with primidone or beta-blockers effectively controls ET tremor, but in many cases no treatment is needed at all" 05/01/2006 - "Mild to moderate tremor usually will respond to oral agents such as noncardiac selective beta-blockers or primidone" 01/01/2006 - "These results suggest that heterozygosis CYP2C191/CYP2C192 is associated with the risk for ET, but not with the age at onset of ET, the presentation of acute side effects of primidone, or the existence of head, voice, tongue or chin tremor." 01/01/2006 - "The mean age at onset of ET did not differ significantly between patients with genotypes CYP2C191/CYP2C192andCYP2C191/CYP2C191. The frequencies of the genotype CYP2C191/CYP2C192 and the allelic variant CYP2C192 were similar in ET patients who developed acute adverse effects to primidone, in those who tolerated primidone and in controls; the frequencies were also similar in patients with head, voice, tongue and chin tremor compared with controls" Get all the results and reference details, order at left...*
4.	Epilepsy (Aura) 06/01/1956 - "Critical study of the value of primidone in the treatment of epilepsy.]" 05/01/2005 - "Primidone is associated with interictal depression in patients with epilepsy." 01/01/1983 - "PB:PRM ratio in patients with epilepsy treated with primidone." 09/15/1982 - "Treatment of canine epilepsy with primidone." 11/01/1979 - "On account of the similarities in metabolism and pharmacokinetics of primidone in dog and man, the former species seems to be a suitable model in epilepsy research" Get all the results and reference details, order at left...
5.	Vomiting 05/01/1987 - "However, primidone was significantly even more effective in the beginning after only 2 doses, when at the same time 10 of 13 patients showed a maximum of acute toxic side-effects producing nausea, vomiting, giddiness and/or sedation" 07/18/1985 - "Differences in failure rates of the drugs were explained primarily by the fact that primidone caused more intolerable acute toxic effects, such as nausea, vomiting, dizziness, and sedation" 05/01/1992 - "Case No. 1 presented with ataxia, lethargy, vomiting, and leaning and falling to the right, and had a transient remission following radiation and corticosteroid therapy; case No. 2 had a history of seizures that were unresponsive to primidone, left-sided postural reaction deficits, ataxia, and circling to the right; case No. 3 had only intermittent episodes of vomiting Computed tomography of case Nos" Get all the results and reference details, order at left...
98 Diseases and 333 more articles analyzed in the Research Interface, order at left...

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