Phenobarbital (Luminal)

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9309 relevant articles (368 outcomes, 715 trials/studies) found for this Drug

Description: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

Also Known As:

Luminal; Gardenal; Phenobarbital Sodium; Hysteps; Phenobarbital, Monosodium Salt; Phenylethylbarbituric Acid; Acid, Phenylethylbarbituric; Monosodium Salt Phenobarbital; Sodium, Phenobarbital; Phenemal; Phenobarbitone; Phenylbarbital; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25

1-Ring Heterocyclic Compounds

1-methyl-5-phenyl-5-propylbarbituric acid: 6

phenobarbital quinidine: 3

1-methyl-5-phenyl-5-butylbarbituric acid: 1

5,5-diphenylbarbituric acid: 1

alnagon: 1

brondiletten retard: 1

compound cycloclenbuterol: 1

dichlorophenobarbital: 1

1-(2,3,4,6-tetraacetyl-beta-D-glucopyranosyl)phenobarbital

1-diethylaminoethylphenobarbital

1-methyl-5-pentyl-5-phenylbarbituric acid

2-thiophenobarbital

3-hydroxyphenobarbital

4-azidophenobarbital

4-hydroxyphenobarbital

5-phenyl-5-(4-aminobutyl)barbituric acid

acecobarb

comital-L

dimethylphenobarbital

exrheudon-dragees

Hydanphene

Kominek's mixture

N,N-dimethyl-2-thiophenobarbital

N,S-dimethyl-2-thiophenobarbital

N-3-benzylphenobarbital

N-methoxymethylphenobarbital

N-methyl-2-thiophenobarbital

phenobarbital-N-glucoside

Quadrinal

S-methyl-2-thiophenobarbital

SR 82 tablets

Experts

1.	Jiang, Dawei: 3 articles (07/2008 - 11/2005)
2.	Chen, S R Wayne: 3 articles (07/2008 - 11/2005)
3.	Wang, Ruiwu: 3 articles (07/2008 - 11/2005)
4.	Zhang, Lin: 3 articles (07/2008 - 11/2005)
5.	Thirunavukkarasu, C: 3 articles (03/2008 - 02/2003)
6.	Sakthisekaran, D: 3 articles (03/2008 - 02/2003)
7.	Charafe-Jauffret, Emmanuelle: 3 articles (02/2008 - 08/2004)
8.	Birnbaum, Daniel: 3 articles (02/2008 - 08/2004)
9.	Jacquemier, Jocelyne: 3 articles (02/2008 - 08/2004)
10.	Bertucci, François: 3 articles (02/2008 - 08/2004)

Related Diseases

1.	Seizures (Seizure) 04/01/1998 - "A marked improvement could be observed for most of the patients treated with phenobarbitone in terms of reduction of seizure frequency although complete seizure control was achieved in only a few." 08/01/1977 - "Complete protection against IPS-induced seizures was observed for a period of 6 h after acute phenobarbital administration during which the mean plasma phenobarbital concentrations were between 16.2 +/- 0.91 and 13.6 +/- 1.0 microgram/lm. " 12/01/2005 - "CONCLUSIONS: Phenobarbital in the dose of 20 mg/kg IV given within six hours of life to term and near-term neonates with HIE, significantly decreased the incidence of neonatal seizures and was well tolerated. " 02/01/2000 - "Phenobarbital (12.5-50 mg/kg, subcutaneously) also significantly decreased the incidence of both convulsions and prolonged their latencies. " 08/01/1999 - "The extract significantly potentiated the phenobarbitone sleeping time in mice and produced a 60% protection against leptazol-induced convulsion. " Order ALL the reference details at left...
2.	Pathologic Constriction (Stenosis) 08/07/2009 - "The area of neointima, mean intima/media ratios, and the percentage of luminal stenosis were significantly greater (P<0.01) in DKO mice. " 10/15/2008 - "We compared both quantitative coronary angiography (QCA) and MSCT to the gold standard for a significant stenosis-minimum luminal area (MLA) by intravascular ultrasound (IVUS)-in 51 patients (64 +/- 10 years old, 19 men) with 69 angiographically ambiguous, nonleft main lesions. " 03/21/2006 - "In coronary arteries with <50% stenosis, there were no temporal changes in luminal and plaque dimensions measured by quantitative coronary angiography or IVUS; however, a significant reduction in abnormal strain pattern was detected on palpography (density high strain spots/cm: 1.6 +/- 1.5 vs. 1.2 +/- 1.4, p = 0.0123. " 07/01/2004 - "Although a relatively high migration rate was observed in patients with benign strictures, stenting was still effective in providing luminal patency (median follow-up, 7.5 months). " 12/01/2002 - "The reduction in late luminal loss (mean (SD) 1.19 (0.87) mm in the optional v 0.62 (0.69) mm in the direct stenting group, p = 0.004) led to a significant improvement in minimal luminal diameter at follow up (1.87 (0.93) mm in the optional v 2.56 (0.86) mm in the direct stenting group, p = 0.002), resulting in a significant reduction in restenosis rate, defined as > 50% diameter stenosis at follow up 6.5 (2.1) months after the initial procedure (28 (30.4%) in the optional v 14 (15.7%) in the direct stenting group, p = 0.019). " Order ALL the reference details at left...
3.	Crohn Disease (Crohn's Disease) 05/16/2009 - "The authors conclude that the three above-mentioned agents are effective in luminal Crohn's disease. " 01/01/1997 - "Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn's disease." 06/01/2008 - "RESULTS: Fourteen luminal Crohn's disease trials enrolled 3995 patients. " 09/01/2002 - "BACKGROUND AND AIMS: Experimental studies have shown that luminal bacteria may be involved in Crohn's disease. " 03/01/2002 - "AIMS: The aim of the study was to investigate the effects of a luminal stimulus, known to affect tight junctions, on the distal ileum in patients with Crohn's disease. " Order ALL the reference details at left...
4.	Epilepsy (Aura) 01/01/2002 - "CONCLUSION: Low doses of phenobarbital were very effective against epilepsy. " 09/01/2006 - "High-dose phenobarbital therapy is effective for refractory epilepsy in patients complicated by respiratory distress. " 01/01/1987 - "Seventy-five children with different nutritional status, who were receiving phenobarbitone for treatment of various seizure disorders, were monitored for their plasma steady state level, therapeutic efficacy and toxicity. " 05/23/2006 - "[Evaluation of the efficacy of phenobarbital in treatment of epilepsy in rural areas: study of 2455 patients in rural China]" 05/23/2006 - "OBJECTIVE: To evaluate the efficacy of phenobarbital in treatment of patients with convulsive forms of epilepsy in rural areas and to develop a suitable relevant model for rural China. " Order ALL the reference details at left...
5.	Febrile Seizures (Febrile Seizure) 01/01/1978 - "Intermittent phenobarbital administration during subsequent, febrile illnesses confers little protection against recurrent, febrile convulsions. " 06/01/1994 - "Although they were developed for measuring the behavioral effects of phenobarbital on children with febrile seizures, these scales provide an objective means of measuring emotional expression and self-regulation useful for other studies." 05/01/1993 - "A randomized double blind placebo controlled trial was carried out to study the effect of phenobarbitone (PB) in preventing recurrences of simple and atypical febrile convulsions among children in the age group 6 months to 6 years. " 03/01/1993 - "The effect of phenobarbital on total sleep time, night awakenings, and lengthy awakenings was examined as part of a randomized trial of children with febrile seizures; information about sleep patterns was gathered by parental observation. " 10/01/1981 - "They study the role of phenobarbital taken after febrile seizures, as prophylaxis. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Phenytoin (Dilantin)
2.	Carbamazepine (Tegretol)
3.	Valproic Acid (Valproate, Semisodium)
4.	Diazepam (Valium)
5.	Anticonvulsants (Antiepileptic Drugs)
6.	infliximab (Remicade)
7.	Primidone (Sertan)
8.	Ethosuximide (Zarontin)
9.	Clonazepam (Rivotril)
10.	Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Stents
3.	Percutaneous Coronary Transluminal Angioplasty (PTCA)
4.	Balloon Angioplasty (Angioplasty, Transluminal)
5.	Lasers (Laser)

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